Matches in SemOpenAlex for { <https://semopenalex.org/work/W1554792051> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W1554792051 endingPage "2189" @default.
- W1554792051 startingPage "2184" @default.
- W1554792051 abstract "Abstract In this paper we have examined the phenomenon of hapten-specific tolerance in the cytolytic T lymphocyte (CTL), using the trinitrophenyl (TNP) and azobenzenearsonate haptens. We found that the H-2 K and H-2 D-end restricted CTL in H-2a mice are differentiable in the ease with which they are tolerized to the TNP hapten. With TNP modified syngeneic spleen cells (TNP-SC), or low amounts of trinitrobenzylsulfonic acid as tolerogen, preferential hyporesponsiveness of D-end restricted CTL can be observed. Larger doses of hapten, e.g. a higher amount of trinitrobenzylsulfonic acid, will tolerize both K- and D-end restricted TNP-specific CTL in H-2a mice. The phenomenon of preferential D-end restricted CTL hyporesponsiveness is not observed in H-2d, H-2k, or H-2b mice, nor is it observed in H-2a mice with respect to the azobenzenearsonate hapten. We have also shown that the clones of CTL responsible for lysis of TNP-modified allogeneic targets (cross-reactive lysis) in H-2a mice probably overlap with the D-end restricted TNP-specific CTL since D-end restricted hyporesponsiveness induced by intravenous injection of TNP spleen cells also results in the elimination of cross-reactive lysis of TNP-modified allogeneic targets. The possible mechanisms of preferential D-end hyporesponsiveness to the TNP hapten in the H-2a mice as well as its significance and relationship to previous work in this area are discussed in this paper." @default.
- W1554792051 created "2016-06-24" @default.
- W1554792051 creator A5001497872 @default.
- W1554792051 creator A5006467772 @default.
- W1554792051 creator A5049353308 @default.
- W1554792051 creator A5050395061 @default.
- W1554792051 date "1983-11-01" @default.
- W1554792051 modified "2023-09-25" @default.
- W1554792051 title "Regulation of the hapten-specific T cell response. I. Preferential induction of hyporesponsiveness to the D-end of the major histocompatibility complex in the hapten-specific cytotoxic T cell response." @default.
- W1554792051 doi "https://doi.org/10.4049/jimmunol.131.5.2184" @default.
- W1554792051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6195256" @default.
- W1554792051 hasPublicationYear "1983" @default.
- W1554792051 type Work @default.
- W1554792051 sameAs 1554792051 @default.
- W1554792051 citedByCount "2" @default.
- W1554792051 crossrefType "journal-article" @default.
- W1554792051 hasAuthorship W1554792051A5001497872 @default.
- W1554792051 hasAuthorship W1554792051A5006467772 @default.
- W1554792051 hasAuthorship W1554792051A5049353308 @default.
- W1554792051 hasAuthorship W1554792051A5050395061 @default.
- W1554792051 hasBestOaLocation W15547920511 @default.
- W1554792051 hasConcept C147969180 @default.
- W1554792051 hasConcept C153911025 @default.
- W1554792051 hasConcept C154317977 @default.
- W1554792051 hasConcept C159654299 @default.
- W1554792051 hasConcept C167672396 @default.
- W1554792051 hasConcept C185592680 @default.
- W1554792051 hasConcept C202751555 @default.
- W1554792051 hasConcept C203014093 @default.
- W1554792051 hasConcept C207936829 @default.
- W1554792051 hasConcept C2776090121 @default.
- W1554792051 hasConcept C2780931953 @default.
- W1554792051 hasConcept C29144244 @default.
- W1554792051 hasConcept C55493867 @default.
- W1554792051 hasConcept C73588182 @default.
- W1554792051 hasConcept C86803240 @default.
- W1554792051 hasConcept C8891405 @default.
- W1554792051 hasConceptScore W1554792051C147969180 @default.
- W1554792051 hasConceptScore W1554792051C153911025 @default.
- W1554792051 hasConceptScore W1554792051C154317977 @default.
- W1554792051 hasConceptScore W1554792051C159654299 @default.
- W1554792051 hasConceptScore W1554792051C167672396 @default.
- W1554792051 hasConceptScore W1554792051C185592680 @default.
- W1554792051 hasConceptScore W1554792051C202751555 @default.
- W1554792051 hasConceptScore W1554792051C203014093 @default.
- W1554792051 hasConceptScore W1554792051C207936829 @default.
- W1554792051 hasConceptScore W1554792051C2776090121 @default.
- W1554792051 hasConceptScore W1554792051C2780931953 @default.
- W1554792051 hasConceptScore W1554792051C29144244 @default.
- W1554792051 hasConceptScore W1554792051C55493867 @default.
- W1554792051 hasConceptScore W1554792051C73588182 @default.
- W1554792051 hasConceptScore W1554792051C86803240 @default.
- W1554792051 hasConceptScore W1554792051C8891405 @default.
- W1554792051 hasIssue "5" @default.
- W1554792051 hasLocation W15547920511 @default.
- W1554792051 hasLocation W15547920512 @default.
- W1554792051 hasOpenAccess W1554792051 @default.
- W1554792051 hasPrimaryLocation W15547920511 @default.
- W1554792051 hasRelatedWork W1541421624 @default.
- W1554792051 hasRelatedWork W1789758664 @default.
- W1554792051 hasRelatedWork W1964986315 @default.
- W1554792051 hasRelatedWork W1968379413 @default.
- W1554792051 hasRelatedWork W1980416103 @default.
- W1554792051 hasRelatedWork W2020986964 @default.
- W1554792051 hasRelatedWork W2146617890 @default.
- W1554792051 hasRelatedWork W2408696062 @default.
- W1554792051 hasRelatedWork W2416987368 @default.
- W1554792051 hasRelatedWork W2896432186 @default.
- W1554792051 hasVolume "131" @default.
- W1554792051 isParatext "false" @default.
- W1554792051 isRetracted "false" @default.
- W1554792051 magId "1554792051" @default.
- W1554792051 workType "article" @default.