FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1554823933> ?p ?o ?g. }

• W1554823933 endingPage "324" @default.
• W1554823933 startingPage "315" @default.
• W1554823933 abstract "Atopic dermatitis (AD) is a chronic inflammatory skin disease with pruritic and eczematous lesions characterized by increased total IgE level, inflammatory cell infiltration, and the elevated expression of Th2 cytokines. Synthetic oligodeoxynucleotides containing unmethylated CpG dinucleotides are known to have immunostimulatory activities in mice and to convert from Th2 to Th1 immune responses in AD. Previous work has shown clinical effectiveness of CpG phosphorothioate-ODN in AD mice model. However, due to longer in vivo half-life and the possibility of causing unwanted side effects, therapeutic use of CpG phosphorothioate-ODN can be limited. Thus, we investigated the efficacy of CpG phosphodiester-ODN with a novel sequence in NC/Nga mice. Topical application of phosphodiester-ODN penetrated rapidly from epidermis to the lymph nodes, accompanied by reduced infiltration of inflammatory cells and decreased number of cells expressing cytokines such as IL-4, IL-10 and IFN-gamma. Furthermore, the expression of IFN-gamma was reduced in the CpG ODNs-treated NC/Nga mice while the expression of IL-12p40 was increased, suggesting stimulation of Th1 immune response. The expression of IL-10 was strongly reduced, which meant the suppression of Th2 immune response in NC/Nga mice, accompanied by reduced level of IgE and IgG1, but increased level of IgG2a in sera. Since phosphodiester-ODN has been shown to cause minimum side effect comparing its phosphorothioate counterpart, it is proposed to become a new therapeutic modality for AD." @default.
• W1554823933 created "2016-06-24" @default.
• W1554823933 creator A5002977194 @default.
• W1554823933 creator A5057375627 @default.
• W1554823933 creator A5060766283 @default.
• W1554823933 creator A5064558238 @default.
• W1554823933 creator A5067254722 @default.
• W1554823933 creator A5072392152 @default.
• W1554823933 date "2007-01-01" @default.
• W1554823933 modified "2023-09-27" @default.
• W1554823933 title "Improvement of Atopic Dermatitis in NC/Nga Mice by Topical Application of CpG Phosphodiester-ODN" @default.
• W1554823933 cites W1503496693 @default.
• W1554823933 cites W1546445911 @default.
• W1554823933 cites W1660215706 @default.
• W1554823933 cites W1756262770 @default.
• W1554823933 cites W1855382573 @default.
• W1554823933 cites W1963771365 @default.
• W1554823933 cites W1970140945 @default.
• W1554823933 cites W1976255646 @default.
• W1554823933 cites W1988461255 @default.
• W1554823933 cites W1991195369 @default.
• W1554823933 cites W2011687160 @default.
• W1554823933 cites W2015564999 @default.
• W1554823933 cites W2015941743 @default.
• W1554823933 cites W2022663932 @default.
• W1554823933 cites W2026990074 @default.
• W1554823933 cites W2040651348 @default.
• W1554823933 cites W2045024700 @default.
• W1554823933 cites W2050436579 @default.
• W1554823933 cites W2058885547 @default.
• W1554823933 cites W2064943953 @default.
• W1554823933 cites W2066211228 @default.
• W1554823933 cites W2091729488 @default.
• W1554823933 cites W2107462315 @default.
• W1554823933 cites W2118011548 @default.
• W1554823933 cites W2122048526 @default.
• W1554823933 cites W2136137780 @default.
• W1554823933 cites W2137722996 @default.
• W1554823933 cites W2143138017 @default.
• W1554823933 cites W2149975799 @default.
• W1554823933 cites W2154376533 @default.
• W1554823933 cites W2156989773 @default.
• W1554823933 cites W2159795335 @default.
• W1554823933 cites W2162754391 @default.
• W1554823933 cites W2169100849 @default.
• W1554823933 cites W2171524621 @default.
• W1554823933 cites W3134986606 @default.
• W1554823933 doi "https://doi.org/10.1159/000106458" @default.
• W1554823933 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17671391" @default.
• W1554823933 hasPublicationYear "2007" @default.
• W1554823933 type Work @default.
• W1554823933 sameAs 1554823933 @default.
• W1554823933 citedByCount "11" @default.
• W1554823933 countsByYear W15548239332012 @default.
• W1554823933 countsByYear W15548239332014 @default.
• W1554823933 countsByYear W15548239332015 @default.
• W1554823933 countsByYear W15548239332019 @default.
• W1554823933 countsByYear W15548239332021 @default.
• W1554823933 countsByYear W15548239332022 @default.
• W1554823933 crossrefType "journal-article" @default.
• W1554823933 hasAuthorship W1554823933A5002977194 @default.
• W1554823933 hasAuthorship W1554823933A5057375627 @default.
• W1554823933 hasAuthorship W1554823933A5060766283 @default.
• W1554823933 hasAuthorship W1554823933A5064558238 @default.
• W1554823933 hasAuthorship W1554823933A5067254722 @default.
• W1554823933 hasAuthorship W1554823933A5072392152 @default.
• W1554823933 hasConcept C104317684 @default.
• W1554823933 hasConcept C140173407 @default.
• W1554823933 hasConcept C141105273 @default.
• W1554823933 hasConcept C150194340 @default.
• W1554823933 hasConcept C150903083 @default.
• W1554823933 hasConcept C159654299 @default.
• W1554823933 hasConcept C185592680 @default.
• W1554823933 hasConcept C190727270 @default.
• W1554823933 hasConcept C203014093 @default.
• W1554823933 hasConcept C207001950 @default.
• W1554823933 hasConcept C22801619 @default.
• W1554823933 hasConcept C2778329239 @default.
• W1554823933 hasConcept C38441620 @default.
• W1554823933 hasConcept C55493867 @default.
• W1554823933 hasConcept C67705224 @default.
• W1554823933 hasConcept C71924100 @default.
• W1554823933 hasConcept C86803240 @default.
• W1554823933 hasConcept C8891405 @default.
• W1554823933 hasConceptScore W1554823933C104317684 @default.
• W1554823933 hasConceptScore W1554823933C140173407 @default.
• W1554823933 hasConceptScore W1554823933C141105273 @default.
• W1554823933 hasConceptScore W1554823933C150194340 @default.
• W1554823933 hasConceptScore W1554823933C150903083 @default.
• W1554823933 hasConceptScore W1554823933C159654299 @default.
• W1554823933 hasConceptScore W1554823933C185592680 @default.
• W1554823933 hasConceptScore W1554823933C190727270 @default.
• W1554823933 hasConceptScore W1554823933C203014093 @default.
• W1554823933 hasConceptScore W1554823933C207001950 @default.
• W1554823933 hasConceptScore W1554823933C22801619 @default.
• W1554823933 hasConceptScore W1554823933C2778329239 @default.
• W1554823933 hasConceptScore W1554823933C38441620 @default.
• W1554823933 hasConceptScore W1554823933C55493867 @default.

• next