Matches in SemOpenAlex for { <https://semopenalex.org/work/W1554837900> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W1554837900 endingPage "336" @default.
- W1554837900 startingPage "330" @default.
- W1554837900 abstract "Background Leukofiltration of blood components is currently implemented worldwide as a precautionary measure against white blood cell–associated adverse effects and the potential transmission of variant Creutzfeldt-Jakob disease (vCJD). A newly developed bifunctional filter (Sepacell Prima, Asahi Kasei Medical) was assessed for prion removal, leukoreduction (LR), and whether the filter significantly affected red blood cells (RBCs). Study Design and Methods Sepacell Prima's postfiltration effects on RBCs, including hemolysis, complement activation, and RBC chemistry, were compared with those of a conventional LR filter (Sepacell Pure RC). Prion removal was measured by Western blot after spiking RBCs with microsomal fractions derived from scrapie-infected hamster brain homogenate. Serially diluted exogenous prion solutions (0.05 mL), with or without filtration, were injected intracerebrally into Golden Syrian hamsters. Results LR efficiency of 4.44 log with the Sepacell Prima was comparable to 4.11 log with the conventional LR filter. There were no significant differences between the two filters in hemoglobin loss, hemolysis, complement activation, and RBC biomarkers. In vitro reduction of exogenously spiked prions by the filter exceeded 3 log. The titer, 6.63 (log ID50/mL), of prefiltration infectivity of healthy hamsters was reduced to 2.52 (log ID50/mL) after filtration. The reduction factor was calculated as 4.20 (log ID50). Conclusion With confirmed removal efficacy for exogenous prion protein, this new bifunctional prion and LR filter should reduce the residual risk of vCJD transmission through blood transfusion without adding complexity to component processing." @default.
- W1554837900 created "2016-06-24" @default.
- W1554837900 creator A5012257998 @default.
- W1554837900 creator A5012940591 @default.
- W1554837900 creator A5036141057 @default.
- W1554837900 creator A5077720857 @default.
- W1554837900 date "2014-09-01" @default.
- W1554837900 modified "2023-10-16" @default.
- W1554837900 title "Development of a bifunctional filter for prion protein and leukoreduction of red blood cell components" @default.
- W1554837900 cites W1521251286 @default.
- W1554837900 cites W1587871588 @default.
- W1554837900 cites W1918095284 @default.
- W1554837900 cites W1967261289 @default.
- W1554837900 cites W1991644458 @default.
- W1554837900 cites W2002762815 @default.
- W1554837900 cites W2014934577 @default.
- W1554837900 cites W2025342409 @default.
- W1554837900 cites W2029511710 @default.
- W1554837900 cites W2083540358 @default.
- W1554837900 cites W2093113522 @default.
- W1554837900 cites W2135237151 @default.
- W1554837900 cites W2137782260 @default.
- W1554837900 cites W2154713296 @default.
- W1554837900 doi "https://doi.org/10.1111/trf.12839" @default.
- W1554837900 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25178436" @default.
- W1554837900 hasPublicationYear "2014" @default.
- W1554837900 type Work @default.
- W1554837900 sameAs 1554837900 @default.
- W1554837900 citedByCount "2" @default.
- W1554837900 countsByYear W15548379002016 @default.
- W1554837900 countsByYear W15548379002018 @default.
- W1554837900 crossrefType "journal-article" @default.
- W1554837900 hasAuthorship W1554837900A5012257998 @default.
- W1554837900 hasAuthorship W1554837900A5012940591 @default.
- W1554837900 hasAuthorship W1554837900A5036141057 @default.
- W1554837900 hasAuthorship W1554837900A5077720857 @default.
- W1554837900 hasConcept C126322002 @default.
- W1554837900 hasConcept C153911025 @default.
- W1554837900 hasConcept C159047783 @default.
- W1554837900 hasConcept C161790260 @default.
- W1554837900 hasConcept C1621761 @default.
- W1554837900 hasConcept C16685009 @default.
- W1554837900 hasConcept C185592680 @default.
- W1554837900 hasConcept C203014093 @default.
- W1554837900 hasConcept C2776557347 @default.
- W1554837900 hasConcept C2776735649 @default.
- W1554837900 hasConcept C2776797465 @default.
- W1554837900 hasConcept C2778575167 @default.
- W1554837900 hasConcept C2779134260 @default.
- W1554837900 hasConcept C2779902561 @default.
- W1554837900 hasConcept C2780014101 @default.
- W1554837900 hasConcept C2780443040 @default.
- W1554837900 hasConcept C2781003276 @default.
- W1554837900 hasConcept C3019804061 @default.
- W1554837900 hasConcept C55493867 @default.
- W1554837900 hasConcept C71924100 @default.
- W1554837900 hasConcept C86803240 @default.
- W1554837900 hasConceptScore W1554837900C126322002 @default.
- W1554837900 hasConceptScore W1554837900C153911025 @default.
- W1554837900 hasConceptScore W1554837900C159047783 @default.
- W1554837900 hasConceptScore W1554837900C161790260 @default.
- W1554837900 hasConceptScore W1554837900C1621761 @default.
- W1554837900 hasConceptScore W1554837900C16685009 @default.
- W1554837900 hasConceptScore W1554837900C185592680 @default.
- W1554837900 hasConceptScore W1554837900C203014093 @default.
- W1554837900 hasConceptScore W1554837900C2776557347 @default.
- W1554837900 hasConceptScore W1554837900C2776735649 @default.
- W1554837900 hasConceptScore W1554837900C2776797465 @default.
- W1554837900 hasConceptScore W1554837900C2778575167 @default.
- W1554837900 hasConceptScore W1554837900C2779134260 @default.
- W1554837900 hasConceptScore W1554837900C2779902561 @default.
- W1554837900 hasConceptScore W1554837900C2780014101 @default.
- W1554837900 hasConceptScore W1554837900C2780443040 @default.
- W1554837900 hasConceptScore W1554837900C2781003276 @default.
- W1554837900 hasConceptScore W1554837900C3019804061 @default.
- W1554837900 hasConceptScore W1554837900C55493867 @default.
- W1554837900 hasConceptScore W1554837900C71924100 @default.
- W1554837900 hasConceptScore W1554837900C86803240 @default.
- W1554837900 hasIssue "2" @default.
- W1554837900 hasLocation W15548379001 @default.
- W1554837900 hasLocation W15548379002 @default.
- W1554837900 hasOpenAccess W1554837900 @default.
- W1554837900 hasPrimaryLocation W15548379001 @default.
- W1554837900 hasRelatedWork W1554837900 @default.
- W1554837900 hasRelatedWork W1918095284 @default.
- W1554837900 hasRelatedWork W2112429959 @default.
- W1554837900 hasRelatedWork W2136908291 @default.
- W1554837900 hasRelatedWork W2142793535 @default.
- W1554837900 hasRelatedWork W2326162430 @default.
- W1554837900 hasRelatedWork W3107437032 @default.
- W1554837900 hasRelatedWork W3137730152 @default.
- W1554837900 hasRelatedWork W4249890631 @default.
- W1554837900 hasRelatedWork W4366251480 @default.
- W1554837900 hasVolume "55" @default.
- W1554837900 isParatext "false" @default.
- W1554837900 isRetracted "false" @default.
- W1554837900 magId "1554837900" @default.
- W1554837900 workType "article" @default.