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- W155487251 abstract "The cotransport of Na+ and electrically neutral organic substances is known to be electrogenic. A large Na+-dependent depolarization of cell membranes has been demonstrated to occur, in both renal proximal tubule and the small intestine, when D-glucose or L-neutral amino acid is added to the luminal fluid. This chapter discusses a method for quantitative determination of various resistance components of the proximal tubule and membrane resistance changes associated with cotransport are reinvestigated in newt kidney. Intraluminal current injection is adopted and the resultant voltage deflections are recorded from various points within the lumen and inside the cells along a nephron. The values of resistances are determined by simulation techniques with the aid of a digital computer. The chapter presents results that show that the luminal membrane resistance decreases considerably while the basal membrane resistance increases when L-alanine is introduced into the tubular lumen. The resistance of the paracellular shunt also changes to a small extent." @default.
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- W155487251 date "1981-01-01" @default.
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- W155487251 title "CHANGES IN MEMBRANE RESISTANCES OF RENAL PROXIMAL TUBULE INDUCED BY COTRANSPORT OF SODIUM AND ORGANIC SOLUTE" @default.
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- W155487251 doi "https://doi.org/10.1016/b978-0-08-026824-8.50055-2" @default.
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