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• W1554889623 abstract "The 2009/10 pandemic (p H 1 N 1) highlighted the need for vaccines conferring heterosubtypic immunity against antigenically shifted influenza strains. Although cross‐reactive T cells are strong candidates for mediating heterosubtypic immunity, little is known about the population‐level prevalence, frequency, and cytokine‐secretion profile of heterosubtypic T cells to p H 1 N 1. To assess this, p H 1 N 1 sero‐negative adults were recruited. Single‐cell IFN ‐γ and IL ‐2 cytokine‐secretion profiles to internal proteins of p H 1 N 1 or live virus were enumerated and characterised. Heterosubtypic T cells recognising p H 1 N 1 core proteins were widely prevalent, being detected in 90% (30 of 33) of p H 1 N 1‐naïve individuals. Although the last exposure to influenza was greater than 6 months ago, the frequency and proportion of the IFN ‐γ‐only‐secreting T ‐cell subset was significantly higher than the IL ‐2‐only‐secreting subset. CD 8 + IFN ‐γ‐only‐secreting heterosubtypic T cells were predominantly CCR 7 − CD 45 RA − effector‐memory phenotype, expressing the tissue‐homing receptor CXCR 3 and degranulation marker CD 107. Receipt of the 2008–09 influenza vaccine did not alter the frequency of these heterosubtypic T cells, highlighting the inability of current vaccines to maintain this heterosubtypic T ‐cell pool. The surprisingly high prevalence of pre‐existing circulating p H 1 N 1‐specific CD 8 + IFN ‐γ‐only‐secreting effector memory T cells with cytotoxic and lung‐homing potential in p H 1 N 1‐seronegative adults may partly explain the low case fatality rate despite high rates of infection of the pandemic in young adults." @default.
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• W1554889623 date "2012-08-15" @default.
• W1554889623 modified "2023-10-16" @default.
• W1554889623 title "Predominance of heterosubtypic IFN-γ-only-secreting effector memory T cells in pandemic H1N1 naive adults" @default.
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• W1554889623 doi "https://doi.org/10.1002/eji.201242504" @default.
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