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- W1554961906 abstract "A significant decline in the numbers of 3,4-dihydroxyphenyalanine (dopa)-reactive epidermal melanocytes has been reported to occur in human skin with advancing age (1, 2). For abdominal skin, this reduction amounts to approximately a loss of 10% of the “surviving” population for each increment of 10 years (2). In contrast, a significant rise in the population of dopa-positive melanocytes within abdominal skin of females takes place during pregnancy and is accompanied by an average increase in the melanogenic activity of each melanocyte (2). A striking increase in dopa-positive melanocytes has also been found in the buttock and abdominal skin of males following repeated exposure to ultraviolet light (3, 4). These observations prompted the present study which deals with the influence of UV on the melanocyte populations of aging human skin. The site selected for examination was the skin of the buttock for reasons already reported (3). The questions to which answers have been sought are: 1) Does an age-dependent decline in the population of dopa-positive melanocytes also occur in the skin of the buttock? 2) If so, does repeated exposure to UV restore their numbers to a common value regardless of age ? MATERIALS AND METHODS Each of twelve adult Caucasian males ranging in age from 27 to 65 years was shielded so that either the left or right buttock was exposed to UV emitted by a General Electric R.S. type sunlamp. The lamp-to-target distance was 15 inches." @default.
- W1554961906 created "2016-06-24" @default.
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- W1554961906 date "1969-03-01" @default.
- W1554961906 modified "2023-10-10" @default.
- W1554961906 title "Influence of Age and UV on the Populations of Dopa-positive Melanocytes in Human Skin**From the Division of Biological and Medical Sciences, Brown University, Providence, R.I., the Department of Dermatology, Harvard Medical School, Massachusetts General Hospital, Boston, Mass., and the Rhode Island Medical Center, Howard, R.I." @default.
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- W1554961906 doi "https://doi.org/10.1038/jid.1969.45" @default.
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