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- W1555097489 endingPage "186" @default.
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- W1555097489 abstract "A large volume of behavioral research has explored the variable number of tandem repeat (VNTR) polymorphism on the dopamine receptor D4 gene (DRD4). However, findings are inconsistent and there is no agreement about what constitutes “functional” and “less functional” variants at this locus. First, we systematically review studies exploring biological differences between DRD4 VNTRs (k = 21). Second, we systematically review studies relating DRD4 variation to behavioral traits in population-based, non-clinical samples of children and adolescents (k = 46; N = 13,195), highlighting the various genotypic classifications previously used. Third, we use meta-analyses to examine associations of DRD4 VNTRs with five broadly-defined behavioral outcomes (externalizing and attention problems, executive function, social/emotional development, and “reactive” temperament). We identify a significant association of “longer” DRD4 variants with lower levels of executive function and social/emotional development, but not independent of the choice of genotypic classification. We suggest that until the functionality of DRD4 VNTRs is established, researchers should report all genotypic classifications to ensure full transparency and allow for further meta-analytic work." @default.
- W1555097489 created "2016-06-24" @default.
- W1555097489 creator A5002903123 @default.
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- W1555097489 creator A5029611311 @default.
- W1555097489 creator A5040046390 @default.
- W1555097489 creator A5077624710 @default.
- W1555097489 date "2015-10-01" @default.
- W1555097489 modified "2023-10-01" @default.
- W1555097489 title "The magnificent seven: A quantitative review of dopamine receptor d4 and its association with child behavior" @default.
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