Matches in SemOpenAlex for { <https://semopenalex.org/work/W1555143218> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W1555143218 abstract "AACR Centennial Conference: Translational Cancer Medicine-- Nov 4-8, 2007; SingaporeC23 Background: Trioxane dimers (TDs) are semi synthetic derivatives of the Chinese antimalarial compound 1,2,4-trioxane artemisinin ( Artemesia annua L., qinghaosu). Second-generation C-10 nonacetal TDs are orally active with high stability, efficacy, and anticancer activity. The cytotoxic effect of artmisinin is likely mediated by free radicals produced by its reaction with intracellular iron, which is dependent on the expression of transferrin receptor (TfR). Pancreatic adenocarcinoma and neuroendocrine carcinoma are characterized by high expression of TfR in contrast to normal pancreatic tissue and benign neuroendocrine tumors of the pancreas. The purpose of this study is to utilize TDs without or with the combination of iron to target TfR overexpressed pancreatic cancer. Methods: in vitro MTT assay to determine cell growth; DNA fragmentation assay to determine apoptosis; flow cytometry and Western blot for expression of transferring receptor. Also pancreatic cancer animal model will be used to determine antitumor activity in vivo . Results: TDs have significant growth inhibitory effects on tested pancreatic cancer cell line Panc-1. This has been shown in time and dose dependent manner with the IC50 range at 25 nM. This dosage has equivalent growth inhibitory effect of Gemcitabine at the concentration between 0.25 uM to 5 uM. Also 25 nM DT can potentiate gemcitabine’s growth inhibitory effect in vitro. In vivo study is in the process now. Conclusions: TDs as potent artemisinin derivatives have significant growth inhibitory effects on pancreatic cancer cells as single agent or in combination with gemcitabine." @default.
- W1555143218 created "2016-06-24" @default.
- W1555143218 creator A5001783218 @default.
- W1555143218 creator A5050431989 @default.
- W1555143218 creator A5058352236 @default.
- W1555143218 creator A5064815806 @default.
- W1555143218 date "2007-11-15" @default.
- W1555143218 modified "2023-09-23" @default.
- W1555143218 title "Potent anticancer activity of the second generation artemisinin-derived trioxane dimers on pancreatic cancer cells." @default.
- W1555143218 hasPublicationYear "2007" @default.
- W1555143218 type Work @default.
- W1555143218 sameAs 1555143218 @default.
- W1555143218 citedByCount "0" @default.
- W1555143218 crossrefType "journal-article" @default.
- W1555143218 hasAuthorship W1555143218A5001783218 @default.
- W1555143218 hasAuthorship W1555143218A5050431989 @default.
- W1555143218 hasAuthorship W1555143218A5058352236 @default.
- W1555143218 hasAuthorship W1555143218A5064815806 @default.
- W1555143218 hasConcept C121608353 @default.
- W1555143218 hasConcept C126322002 @default.
- W1555143218 hasConcept C150903083 @default.
- W1555143218 hasConcept C185592680 @default.
- W1555143218 hasConcept C203014093 @default.
- W1555143218 hasConcept C207001950 @default.
- W1555143218 hasConcept C2776120307 @default.
- W1555143218 hasConcept C2778048844 @default.
- W1555143218 hasConcept C2778371730 @default.
- W1555143218 hasConcept C2778764654 @default.
- W1555143218 hasConcept C2779691961 @default.
- W1555143218 hasConcept C2780210213 @default.
- W1555143218 hasConcept C2780258809 @default.
- W1555143218 hasConcept C2780783641 @default.
- W1555143218 hasConcept C502942594 @default.
- W1555143218 hasConcept C55493867 @default.
- W1555143218 hasConcept C62112901 @default.
- W1555143218 hasConcept C71924100 @default.
- W1555143218 hasConcept C86803240 @default.
- W1555143218 hasConcept C98274493 @default.
- W1555143218 hasConceptScore W1555143218C121608353 @default.
- W1555143218 hasConceptScore W1555143218C126322002 @default.
- W1555143218 hasConceptScore W1555143218C150903083 @default.
- W1555143218 hasConceptScore W1555143218C185592680 @default.
- W1555143218 hasConceptScore W1555143218C203014093 @default.
- W1555143218 hasConceptScore W1555143218C207001950 @default.
- W1555143218 hasConceptScore W1555143218C2776120307 @default.
- W1555143218 hasConceptScore W1555143218C2778048844 @default.
- W1555143218 hasConceptScore W1555143218C2778371730 @default.
- W1555143218 hasConceptScore W1555143218C2778764654 @default.
- W1555143218 hasConceptScore W1555143218C2779691961 @default.
- W1555143218 hasConceptScore W1555143218C2780210213 @default.
- W1555143218 hasConceptScore W1555143218C2780258809 @default.
- W1555143218 hasConceptScore W1555143218C2780783641 @default.
- W1555143218 hasConceptScore W1555143218C502942594 @default.
- W1555143218 hasConceptScore W1555143218C55493867 @default.
- W1555143218 hasConceptScore W1555143218C62112901 @default.
- W1555143218 hasConceptScore W1555143218C71924100 @default.
- W1555143218 hasConceptScore W1555143218C86803240 @default.
- W1555143218 hasConceptScore W1555143218C98274493 @default.
- W1555143218 hasLocation W15551432181 @default.
- W1555143218 hasOpenAccess W1555143218 @default.
- W1555143218 hasPrimaryLocation W15551432181 @default.
- W1555143218 hasRelatedWork W1957820252 @default.
- W1555143218 hasRelatedWork W1995883964 @default.
- W1555143218 hasRelatedWork W1997738462 @default.
- W1555143218 hasRelatedWork W2007597753 @default.
- W1555143218 hasRelatedWork W2061225164 @default.
- W1555143218 hasRelatedWork W2061301688 @default.
- W1555143218 hasRelatedWork W2091344322 @default.
- W1555143218 hasRelatedWork W2315162855 @default.
- W1555143218 hasRelatedWork W2391029797 @default.
- W1555143218 hasRelatedWork W2493884326 @default.
- W1555143218 hasRelatedWork W2565596567 @default.
- W1555143218 hasRelatedWork W2608812892 @default.
- W1555143218 hasRelatedWork W2742470538 @default.
- W1555143218 hasRelatedWork W2744108643 @default.
- W1555143218 hasRelatedWork W2747163356 @default.
- W1555143218 hasRelatedWork W2753593237 @default.
- W1555143218 hasRelatedWork W2938888563 @default.
- W1555143218 hasRelatedWork W3012417792 @default.
- W1555143218 hasRelatedWork W3112821151 @default.
- W1555143218 hasRelatedWork W3120732835 @default.
- W1555143218 hasVolume "13" @default.
- W1555143218 isParatext "false" @default.
- W1555143218 isRetracted "false" @default.
- W1555143218 magId "1555143218" @default.
- W1555143218 workType "article" @default.