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• W1555153550 abstract "Nitric oxide (NO) and cisplatin releasing wrinkle-structured amine-modified mesoporous silica (AMS) nanoparticles have been developed for the treatment of non-small cell lung cancer (NSCLC). The AMS and NO- and cisplatin-loaded AMS materials were characterized using TEM, BET surface area, FTIR and ICP-MS, and tested in cell culture. The results show that for NSCLC cell lines (i.e., H596 and A549), the toxicity of NO- and cisplatin-loaded silica nanoparticles (NO-Si-DETA-cisplatin-AMS) is significantly higher than that of silica nanoparticles loaded with only cisplatin (Si-DETA-cisplatin-AMS). In contrast, the toxicity of NO-Si-DETA-cisplatin-AMS toward normal lung cell lines is not significantly different from that of Si-DETA-cisplatin-AMS (normal lung fibroblast cells WI-38) or is even lower than that of Si-DETA-cisplatin-AMS (normal lung epithelial cells BEAS-2B). The NO-induced sensitization of tumor cell death demonstrates that NO is a promising enhancer of platinum-based lung cancer therapy." @default.
• W1555153550 created "2016-06-24" @default.
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• W1555153550 date "2015-12-01" @default.
• W1555153550 modified "2023-10-17" @default.
• W1555153550 title "Nitric oxide- and cisplatin-releasing silica nanoparticles for use against non-small cell lung cancer" @default.
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• W1555153550 doi "https://doi.org/10.1016/j.jinorgbio.2015.09.002" @default.
• W1555153550 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26402659" @default.
• W1555153550 hasPublicationYear "2015" @default.
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