FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1555242511> ?p ?o ?g. }

• W1555242511 endingPage "17536" @default.
• W1555242511 startingPage "17531" @default.
• W1555242511 abstract "The crystal structure of RNase T1 complexed with 3'-GMP has been determined. The glycosyl conformation of 3'-GMP is in the syn conformation, and the ribose adopts the O4'-endo pucker. This observed pucker is different from that in any complex structures of RNase T1. In the present complex, this energetically unfavorable conformation is stabilized by the water molecule with the bridged hydrogen bonds between the O2' and the O3' atoms of the ribose. The guanine base is recognized in the same manner as observed in the complex of 2'-GMP. The 2'-hydroxyl group of the ribose shows a tight hydrogen bond to both His-40 and Glu-58 with the suitable geometry for the proton transfer. These hydrogen bonds suggest that the two residues can participate directly in the proton transfer. His-92 is hydrogen bonded to two the proton transfer. His-92 is hydrogen bonded to two oxygen atoms of the phosphate group. Based on the geometry in the active site, the O1P atom may correspond to the O5' atom of the leaving nucleotide in the phosphoryl transfer or a water molecule as a nucleophile in the hydrolysis reaction. In the present complex, the conformations of the 3'-GMP molecule and the side chains of the catalytic residues would be represented as the conformation before the phosphoryl transfer reaction and/or after the hydrolysis reaction." @default.
• W1555242511 created "2016-06-24" @default.
• W1555242511 creator A5009468301 @default.
• W1555242511 creator A5015004660 @default.
• W1555242511 creator A5015092891 @default.
• W1555242511 creator A5015447547 @default.
• W1555242511 date "1994-07-01" @default.
• W1555242511 modified "2023-09-28" @default.
• W1555242511 title "Crystal structure of RNase T1 complexed with the product nucleotide 3'-GMP. Structural evidence for direct interaction of histidine 40 and glutamic acid 58 with the 2'-hydroxyl group of the ribose." @default.
• W1555242511 cites W1410743297 @default.
• W1555242511 cites W1521900320 @default.
• W1555242511 cites W1553561420 @default.
• W1555242511 cites W1613515614 @default.
• W1555242511 cites W1865943927 @default.
• W1555242511 cites W1896362284 @default.
• W1555242511 cites W1933901144 @default.
• W1555242511 cites W1965995093 @default.
• W1555242511 cites W1966041739 @default.
• W1555242511 cites W1969222787 @default.
• W1555242511 cites W1975914851 @default.
• W1555242511 cites W1977657958 @default.
• W1555242511 cites W1985418326 @default.
• W1555242511 cites W1986333824 @default.
• W1555242511 cites W1987498725 @default.
• W1555242511 cites W1988243217 @default.
• W1555242511 cites W1989387701 @default.
• W1555242511 cites W2001327360 @default.
• W1555242511 cites W2019590135 @default.
• W1555242511 cites W2030263274 @default.
• W1555242511 cites W2034947201 @default.
• W1555242511 cites W2038112788 @default.
• W1555242511 cites W2042987185 @default.
• W1555242511 cites W2050666834 @default.
• W1555242511 cites W2059242137 @default.
• W1555242511 cites W2059401704 @default.
• W1555242511 cites W2059775875 @default.
• W1555242511 cites W2060448324 @default.
• W1555242511 cites W2061822610 @default.
• W1555242511 cites W2063590540 @default.
• W1555242511 cites W2065717154 @default.
• W1555242511 cites W2066182307 @default.
• W1555242511 cites W2067358859 @default.
• W1555242511 cites W2070535247 @default.
• W1555242511 cites W2084163900 @default.
• W1555242511 cites W2084763593 @default.
• W1555242511 cites W2086449469 @default.
• W1555242511 cites W2094297839 @default.
• W1555242511 cites W2095040802 @default.
• W1555242511 cites W2095453123 @default.
• W1555242511 cites W2160735624 @default.
• W1555242511 cites W2168869451 @default.
• W1555242511 cites W2343041110 @default.
• W1555242511 cites W2695686 @default.
• W1555242511 cites W2949413028 @default.
• W1555242511 cites W2953168281 @default.
• W1555242511 doi "https://doi.org/10.2210/pdb1rls/pdb" @default.
• W1555242511 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7912696" @default.
• W1555242511 hasPublicationYear "1994" @default.
• W1555242511 type Work @default.
• W1555242511 sameAs 1555242511 @default.
• W1555242511 citedByCount "4" @default.
• W1555242511 countsByYear W15552425112022 @default.
• W1555242511 crossrefType "component" @default.
• W1555242511 hasAuthorship W1555242511A5009468301 @default.
• W1555242511 hasAuthorship W1555242511A5015004660 @default.
• W1555242511 hasAuthorship W1555242511A5015092891 @default.
• W1555242511 hasAuthorship W1555242511A5015447547 @default.
• W1555242511 hasConcept C104317684 @default.
• W1555242511 hasConcept C10879258 @default.
• W1555242511 hasConcept C112887158 @default.
• W1555242511 hasConcept C115624301 @default.
• W1555242511 hasConcept C161790260 @default.
• W1555242511 hasConcept C178790620 @default.
• W1555242511 hasConcept C178907741 @default.
• W1555242511 hasConcept C181199279 @default.
• W1555242511 hasConcept C185592680 @default.
• W1555242511 hasConcept C2778301229 @default.
• W1555242511 hasConcept C2778460671 @default.
• W1555242511 hasConcept C2779461342 @default.
• W1555242511 hasConcept C32909587 @default.
• W1555242511 hasConcept C41183919 @default.
• W1555242511 hasConcept C512185932 @default.
• W1555242511 hasConcept C55493867 @default.
• W1555242511 hasConcept C67705224 @default.
• W1555242511 hasConcept C71240020 @default.
• W1555242511 hasConcept C8010536 @default.
• W1555242511 hasConceptScore W1555242511C104317684 @default.
• W1555242511 hasConceptScore W1555242511C10879258 @default.
• W1555242511 hasConceptScore W1555242511C112887158 @default.
• W1555242511 hasConceptScore W1555242511C115624301 @default.
• W1555242511 hasConceptScore W1555242511C161790260 @default.
• W1555242511 hasConceptScore W1555242511C178790620 @default.
• W1555242511 hasConceptScore W1555242511C178907741 @default.
• W1555242511 hasConceptScore W1555242511C181199279 @default.
• W1555242511 hasConceptScore W1555242511C185592680 @default.
• W1555242511 hasConceptScore W1555242511C2778301229 @default.
• W1555242511 hasConceptScore W1555242511C2778460671 @default.
• W1555242511 hasConceptScore W1555242511C2779461342 @default.

• next