Matches in SemOpenAlex for { <https://semopenalex.org/work/W1555334454> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W1555334454 endingPage "7" @default.
- W1555334454 startingPage "1" @default.
- W1555334454 abstract "obesity and diabetes mellitus(1, 5). Leptin has also been implicated in the brain function as well as in the immune and reproductive systems(reviewed in 6, 7). Moreover, leptin plays an important role in brain development. Volume, weight and DNA content of the brain were shown to be reduced in adult ob/ob and db/db mice compared to wildtype controls(7, 8)and these impairments in ob/ob mice are rescued by injection of leptin in juveniles, suggesting that leptin increased the total number of the cells in the brain(10, 11). Our previous study suggested that leptin maintains neural progenitors and is related to glial and neuronal development in mouse embryonic cerebral cortex(7, 12). While we also showed that leptin receptor is expressed in the embryonic cerebellar cortex(13), role of leptin in the cerebellar development remains unclear. In this study, therefore, we investigated the role of leptin in the development of the cerebellum, in particular at the early stage, by comparing the effect of exogenously-injected leptin on the cerebellum between db/db and wild-type embryos. We injected leptin into the cerebral ventricle of mouse embryos on embryonic day (E)14 by exo utero system(14) and analyzed the effect on E16. During this period, progenitor cells of future granule cell are accumulated in the external germinal layer(EGL) (15), while Purkinje cells are migrated from their progenitors in the ventricular zone and produced in the Purkinje cell layer(PCL) (16). The present leptin treatment did not affect EGL cells but exhibited suggestive effects on the development of PCL cells." @default.
- W1555334454 created "2016-06-24" @default.
- W1555334454 creator A5072183578 @default.
- W1555334454 creator A5088672824 @default.
- W1555334454 date "2010-12-01" @default.
- W1555334454 modified "2023-09-23" @default.
- W1555334454 title "Possible Roles of Leptin in the Early Stage of PrenatalDevelopment of the Mouse Cerebellum" @default.
- W1555334454 cites W2007675951 @default.
- W1555334454 cites W2013583119 @default.
- W1555334454 cites W2073311171 @default.
- W1555334454 cites W2082657812 @default.
- W1555334454 cites W2100826819 @default.
- W1555334454 cites W2167253118 @default.
- W1555334454 cites W39318566 @default.
- W1555334454 hasPublicationYear "2010" @default.
- W1555334454 type Work @default.
- W1555334454 sameAs 1555334454 @default.
- W1555334454 citedByCount "0" @default.
- W1555334454 crossrefType "journal-article" @default.
- W1555334454 hasAuthorship W1555334454A5072183578 @default.
- W1555334454 hasAuthorship W1555334454A5088672824 @default.
- W1555334454 hasConcept C104317684 @default.
- W1555334454 hasConcept C126322002 @default.
- W1555334454 hasConcept C134018914 @default.
- W1555334454 hasConcept C14372207 @default.
- W1555334454 hasConcept C145103041 @default.
- W1555334454 hasConcept C196843134 @default.
- W1555334454 hasConcept C201750760 @default.
- W1555334454 hasConcept C2776464000 @default.
- W1555334454 hasConcept C2778888523 @default.
- W1555334454 hasConcept C2779652256 @default.
- W1555334454 hasConcept C2780613262 @default.
- W1555334454 hasConcept C28328180 @default.
- W1555334454 hasConcept C511355011 @default.
- W1555334454 hasConcept C529278444 @default.
- W1555334454 hasConcept C54355233 @default.
- W1555334454 hasConcept C71924100 @default.
- W1555334454 hasConcept C86803240 @default.
- W1555334454 hasConcept C95444343 @default.
- W1555334454 hasConceptScore W1555334454C104317684 @default.
- W1555334454 hasConceptScore W1555334454C126322002 @default.
- W1555334454 hasConceptScore W1555334454C134018914 @default.
- W1555334454 hasConceptScore W1555334454C14372207 @default.
- W1555334454 hasConceptScore W1555334454C145103041 @default.
- W1555334454 hasConceptScore W1555334454C196843134 @default.
- W1555334454 hasConceptScore W1555334454C201750760 @default.
- W1555334454 hasConceptScore W1555334454C2776464000 @default.
- W1555334454 hasConceptScore W1555334454C2778888523 @default.
- W1555334454 hasConceptScore W1555334454C2779652256 @default.
- W1555334454 hasConceptScore W1555334454C2780613262 @default.
- W1555334454 hasConceptScore W1555334454C28328180 @default.
- W1555334454 hasConceptScore W1555334454C511355011 @default.
- W1555334454 hasConceptScore W1555334454C529278444 @default.
- W1555334454 hasConceptScore W1555334454C54355233 @default.
- W1555334454 hasConceptScore W1555334454C71924100 @default.
- W1555334454 hasConceptScore W1555334454C86803240 @default.
- W1555334454 hasConceptScore W1555334454C95444343 @default.
- W1555334454 hasLocation W15553344541 @default.
- W1555334454 hasOpenAccess W1555334454 @default.
- W1555334454 hasPrimaryLocation W15553344541 @default.
- W1555334454 hasRelatedWork W1977534914 @default.
- W1555334454 hasRelatedWork W2059700149 @default.
- W1555334454 hasRelatedWork W2063452973 @default.
- W1555334454 hasRelatedWork W2069833326 @default.
- W1555334454 hasRelatedWork W2069985888 @default.
- W1555334454 hasRelatedWork W2070729834 @default.
- W1555334454 hasRelatedWork W2071465152 @default.
- W1555334454 hasRelatedWork W2073132846 @default.
- W1555334454 hasRelatedWork W2089156150 @default.
- W1555334454 hasRelatedWork W2091895229 @default.
- W1555334454 hasRelatedWork W2100210477 @default.
- W1555334454 hasRelatedWork W2111631797 @default.
- W1555334454 hasRelatedWork W2289229891 @default.
- W1555334454 hasRelatedWork W2527538123 @default.
- W1555334454 hasRelatedWork W2883886520 @default.
- W1555334454 hasRelatedWork W2918648567 @default.
- W1555334454 hasRelatedWork W2950333392 @default.
- W1555334454 hasRelatedWork W2971923367 @default.
- W1555334454 hasRelatedWork W2122229671 @default.
- W1555334454 hasRelatedWork W2404091888 @default.
- W1555334454 hasVolume "27" @default.
- W1555334454 isParatext "false" @default.
- W1555334454 isRetracted "false" @default.
- W1555334454 magId "1555334454" @default.
- W1555334454 workType "article" @default.