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- W1555363564 abstract "Human centromeres are comprised of millions of base pairs of tandemly repeated deoxyribonucleic acid (DNA) sequences. Contrary to the expectation that centromeric sequences would be extremely constrained for centromere function throughout primate evolution, these sequences represent some of the most rapidly evolving sequences in the genome. This rapid evolution in spite of conserved function has been referred to as the ‘centromere paradox’, and it is hypothesized that an ancient, ongoing genetic conflict is at the heart of this rapid evolution.Keywords:chromosome inheritance;mutation;molecular evolution;genetic conflict;epigenetics" @default.
- W1555363564 created "2016-06-24" @default.
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- W1555363564 date "2008-04-30" @default.
- W1555363564 modified "2023-10-01" @default.
- W1555363564 title "The Evolution of Centromeric DNA Sequences" @default.
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- W1555363564 doi "https://doi.org/10.1002/9780470015902.a0020827" @default.
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