Matches in SemOpenAlex for { <https://semopenalex.org/work/W1555419238> ?p ?o ?g. }
- W1555419238 endingPage "30" @default.
- W1555419238 startingPage "4" @default.
- W1555419238 abstract "A hydroalcoholic gel containing estradiol-17 beta (0.6 mg/g) for percutaneous application was used for estrogen replacement therapy in postmenopausal women. During treatment the serum concentrations of estrogens were significantly increased and stable. The conversion of estradiol into estrone was far less pronounced after percutaneous vis-à-vis oral therapy. In terms of FSH suppression the estrogenic potency of percutaneous estradiol-17 beta 3 mg daily was similar to that of oral estradiol-17 beta 2 mg. The serum concentrations of three estrogen-sensitive liver proteins--sex hormone binding globulin (SHBG), pregnancy zone protein (PZP) and ceruloplasmin--were unchanged during percutaneous treatment, whereas during oral therapy all three proteins showed a marked increase. The endometrial response was quantified by morphometry. The mean relative endometrial gland volume increased from 10% to 40% and was correlated to serum levels of estradiol-17 beta. Single-cell growth did not reveal the same correlation and the sequential addition of lynestrenol, 5 mg daily for ten days, did not reduce the estrogen-induced endometrial growth. No obviously harmful local effects were observed in skin samples. Topical application of estradiol-17 beta may develop into an alternative treatment for climacteric complaints and may even have some metabolic advantages over oral treatment." @default.
- W1555419238 created "2016-06-24" @default.
- W1555419238 creator A5078812806 @default.
- W1555419238 date "1983-01-01" @default.
- W1555419238 modified "2023-09-26" @default.
- W1555419238 title "Percutaneous Estrogen Therapy" @default.
- W1555419238 cites W112176633 @default.
- W1555419238 cites W1451684643 @default.
- W1555419238 cites W147643114 @default.
- W1555419238 cites W1577432369 @default.
- W1555419238 cites W1792258421 @default.
- W1555419238 cites W1813330275 @default.
- W1555419238 cites W1878728771 @default.
- W1555419238 cites W1922526566 @default.
- W1555419238 cites W1951608793 @default.
- W1555419238 cites W1964711800 @default.
- W1555419238 cites W1966239078 @default.
- W1555419238 cites W1966487161 @default.
- W1555419238 cites W1969378444 @default.
- W1555419238 cites W1969768261 @default.
- W1555419238 cites W1981410094 @default.
- W1555419238 cites W1981573872 @default.
- W1555419238 cites W1981843591 @default.
- W1555419238 cites W1983190335 @default.
- W1555419238 cites W1989448158 @default.
- W1555419238 cites W1992502576 @default.
- W1555419238 cites W1995284406 @default.
- W1555419238 cites W1997329511 @default.
- W1555419238 cites W1999580128 @default.
- W1555419238 cites W2002235955 @default.
- W1555419238 cites W2003333593 @default.
- W1555419238 cites W2007840376 @default.
- W1555419238 cites W2008362821 @default.
- W1555419238 cites W2008592580 @default.
- W1555419238 cites W2010163801 @default.
- W1555419238 cites W2010657017 @default.
- W1555419238 cites W2012458309 @default.
- W1555419238 cites W2016592632 @default.
- W1555419238 cites W2024081089 @default.
- W1555419238 cites W2033785962 @default.
- W1555419238 cites W2043738450 @default.
- W1555419238 cites W2043829455 @default.
- W1555419238 cites W2045524944 @default.
- W1555419238 cites W2047016426 @default.
- W1555419238 cites W2050266344 @default.
- W1555419238 cites W2053549773 @default.
- W1555419238 cites W2054877457 @default.
- W1555419238 cites W2057474809 @default.
- W1555419238 cites W2067387261 @default.
- W1555419238 cites W2068691239 @default.
- W1555419238 cites W2073018115 @default.
- W1555419238 cites W2073517847 @default.
- W1555419238 cites W2086780680 @default.
- W1555419238 cites W2092484908 @default.
- W1555419238 cites W2110011367 @default.
- W1555419238 cites W2112684706 @default.
- W1555419238 cites W2114308575 @default.
- W1555419238 cites W2126888878 @default.
- W1555419238 cites W2132659221 @default.
- W1555419238 cites W2134049170 @default.
- W1555419238 cites W2140197238 @default.
- W1555419238 cites W2141242014 @default.
- W1555419238 cites W2143678400 @default.
- W1555419238 cites W2163938658 @default.
- W1555419238 cites W2164793526 @default.
- W1555419238 cites W2170104170 @default.
- W1555419238 cites W2266223314 @default.
- W1555419238 cites W2307895602 @default.
- W1555419238 cites W2338124628 @default.
- W1555419238 cites W2343848055 @default.
- W1555419238 cites W2394932821 @default.
- W1555419238 cites W2396855045 @default.
- W1555419238 cites W2396908811 @default.
- W1555419238 cites W2399716893 @default.
- W1555419238 cites W2404262281 @default.
- W1555419238 cites W2409563559 @default.
- W1555419238 cites W2411678947 @default.
- W1555419238 cites W2418177521 @default.
- W1555419238 cites W2775186493 @default.
- W1555419238 cites W2906514890 @default.
- W1555419238 cites W2996479446 @default.
- W1555419238 cites W340680525 @default.
- W1555419238 cites W85529425 @default.
- W1555419238 cites W1823733789 @default.
- W1555419238 cites W3149084304 @default.
- W1555419238 doi "https://doi.org/10.3109/00016348309155363" @default.
- W1555419238 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6574685" @default.
- W1555419238 hasPublicationYear "1983" @default.
- W1555419238 type Work @default.
- W1555419238 sameAs 1555419238 @default.
- W1555419238 citedByCount "12" @default.
- W1555419238 countsByYear W15554192382019 @default.
- W1555419238 crossrefType "journal-article" @default.
- W1555419238 hasAuthorship W1555419238A5078812806 @default.
- W1555419238 hasConcept C126322002 @default.
- W1555419238 hasConcept C134018914 @default.
- W1555419238 hasConcept C2777164284 @default.
- W1555419238 hasConcept C2777911890 @default.