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• W1555543923 abstract "Most differentiated CD 8 + T cells die off at the end of an infection, revealing two main subsets of memory T cells — central and effector memory — which can be found in lymphoid tissues or circulating through nonlymphoid organs, respectively. The cell intrinsic regulation of the differentiation of CD 8 + T cells to effector and central memory remains poorly studied. Herein, we describe a novel role of the ETS transcription factor ELF 4 in the development and function of memory CD 8 + T cells following infection with L isteria monocytogenes . Adoptively transferred Elf4 −/− naïve CD 8 + T cells produced lower numbers of effector memory CD 8 + T cells despite a normal pool of central memory. This was caused by suboptimal priming and decreased survival of CD 8 + T cells at the peak of response while enhanced N otch1 signaling and upregulation of eomesodermin correlated with “normal” development of E lf4 −/− central memory. Finally, loss of ELF 4 impaired the expansion of both central and effector memory CD 8 + T cells in a recall response by also activating N otch1 signaling. Altogether, ELF 4 emerges as a novel transcriptional regulator of CD 8 + T ‐cell differentiation in response to infection." @default.
• W1555543923 created "2016-06-24" @default.
• W1555543923 creator A5019389611 @default.
• W1555543923 creator A5082926384 @default.
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• W1555543923 date "2014-01-13" @default.
• W1555543923 modified "2023-10-16" @default.
• W1555543923 title "Transcription factor ELF4 promotes development and function of memory CD8⁺T cells in<i>Listeria monocytogenes</i>infection" @default.
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• W1555543923 doi "https://doi.org/10.1002/eji.201343775" @default.
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