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- W1555546972 abstract "Raised atherosclerotic lesions were divided into two main types on a histological basis: (1) fatty lesions in which the lipid was primarily within fat-filled cells; (2) fibrous lesions which contained collagen and no fat-filled cells. Both types of lesion were then sub-divided into early stages, in which all the sudanophilic lipid is within fat filled cells (type 1) or in the form of intact perifibrous lipid (type 2), and later stages in which there is a central area of extracellular “amorphous” lipid. Lipid analyses were made on whole small lesions of both types and stages, and on the dissected caps and amorphous centres of larger lesions. The cholesterol ester fatty acid composition was completely different in the two types of lesion: fatty lesions with no amorphous lipid contained 53% oleic acid and 13% linoleic acid, whereas fibrous lesions with no amorphous lipid contained 25 % oleic acid and 43 % linoleic acid. In lesions with amorphous lipid the percentage of free cholesterol increases, and this is highly correlated with changes in the proportions of oleic and linoleic acid. In each type of lesion the proportion of the most abundant acid falls with increasing percentage of cholesterol in the free form (fatty plaques-oleic acid; r=−0.765, P < 0.001 ; fibrous plaques-linoleic acid; r = −0.674, P = 0.001). This suggests that enzymic hydrolysis of cholesterol ester is occurring. The ratio of cholesterol to phospholipid increases significantly in fibrous but not in fatty lesions." @default.
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- W1555546972 date "1968-01-01" @default.
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- W1555546972 title "The lipids in raised fatty and fibrous lesions in human aorta" @default.
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- W1555546972 doi "https://doi.org/10.1016/s0368-1319(68)80097-3" @default.
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