Matches in SemOpenAlex for { <https://semopenalex.org/work/W1555686989> ?p ?o ?g. }
- W1555686989 endingPage "JEN.S2290" @default.
- W1555686989 startingPage "JEN.S2290" @default.
- W1555686989 abstract "It is now clearly established that steroids can be synthesized de novo by the vertebrate brain. Such steroids are called neurosteroids. To understand neurosteroid action in the brain, data on the regio- and temporal-specific synthesis of neurosteroids are needed. In the middle 1990s, the Purkinje cell, an important cerebellar neuron, was identified as a major site for neurosteroid formation in vertebrates. This discovery has allowed deeper insights into neuronal neurosteroidogenesis and biological actions of neurosteroids have become clear by the studies using the Purkinje cell as an excellent cellular model, which is known to play an important role in memory and learning processes. From the past 10 years of research on mammals, we now know that the Purkinje cell actively synthesizes progesterone and estradiol de novo from cholesterol during neonatal life, when cerebellar neuronal circuit formation occurs. Both progesterone and estradiol promote dendritic growth, spinogenesis, and synaptogenesis via each cognate nuclear receptor in the developing Purkinje cell. Such neurosteroid actions that may be mediated by neurotrophic factors contribute to the formation of cerebellar neuronal circuit during neonatal life. Allopregnanolone, a progesterone metabolite, is also synthesized in the cerebellum and acts on Purkinje cell survival in the neonate. The aim of this review is to summarize the current knowledge regarding the biosynthesis and biological actions of neurosteroids in the Purkinje cell during development." @default.
- W1555686989 created "2016-06-24" @default.
- W1555686989 creator A5074471026 @default.
- W1555686989 date "2009-01-01" @default.
- W1555686989 modified "2023-09-24" @default.
- W1555686989 title "Neurosteroid Biosynthesis and Action in the Purkinje Cell" @default.
- W1555686989 cites W1484168868 @default.
- W1555686989 cites W1580685922 @default.
- W1555686989 cites W1610204701 @default.
- W1555686989 cites W1783731643 @default.
- W1555686989 cites W1796427658 @default.
- W1555686989 cites W1847150988 @default.
- W1555686989 cites W1850032865 @default.
- W1555686989 cites W1921580387 @default.
- W1555686989 cites W1956227640 @default.
- W1555686989 cites W1969552181 @default.
- W1555686989 cites W1969715795 @default.
- W1555686989 cites W1971665655 @default.
- W1555686989 cites W1973806002 @default.
- W1555686989 cites W1974028588 @default.
- W1555686989 cites W1975759742 @default.
- W1555686989 cites W1976707885 @default.
- W1555686989 cites W1976917710 @default.
- W1555686989 cites W1978278056 @default.
- W1555686989 cites W1982710339 @default.
- W1555686989 cites W198779817 @default.
- W1555686989 cites W1988215855 @default.
- W1555686989 cites W1990740300 @default.
- W1555686989 cites W1992919675 @default.
- W1555686989 cites W1994879786 @default.
- W1555686989 cites W1995051006 @default.
- W1555686989 cites W1995255923 @default.
- W1555686989 cites W1995832932 @default.
- W1555686989 cites W2003054343 @default.
- W1555686989 cites W2005080856 @default.
- W1555686989 cites W2005825322 @default.
- W1555686989 cites W2008079372 @default.
- W1555686989 cites W2010667807 @default.
- W1555686989 cites W2010828018 @default.
- W1555686989 cites W2011716448 @default.
- W1555686989 cites W2012054377 @default.
- W1555686989 cites W2013985352 @default.
- W1555686989 cites W2015361682 @default.
- W1555686989 cites W2015417034 @default.
- W1555686989 cites W2016112462 @default.
- W1555686989 cites W2023357131 @default.
- W1555686989 cites W2025562313 @default.
- W1555686989 cites W2027730844 @default.
- W1555686989 cites W2030380478 @default.
- W1555686989 cites W2034405963 @default.
- W1555686989 cites W2034509805 @default.
- W1555686989 cites W2035244476 @default.
- W1555686989 cites W2039348556 @default.
- W1555686989 cites W2041760207 @default.
- W1555686989 cites W2042820631 @default.
- W1555686989 cites W2043981633 @default.
- W1555686989 cites W2045559518 @default.
- W1555686989 cites W2046137253 @default.
- W1555686989 cites W2046475191 @default.
- W1555686989 cites W2046524470 @default.
- W1555686989 cites W2048463939 @default.
- W1555686989 cites W2052243272 @default.
- W1555686989 cites W2054476631 @default.
- W1555686989 cites W2055929776 @default.
- W1555686989 cites W2059819603 @default.
- W1555686989 cites W2063670821 @default.
- W1555686989 cites W2064653933 @default.
- W1555686989 cites W2068259898 @default.
- W1555686989 cites W2070072741 @default.
- W1555686989 cites W2070489509 @default.
- W1555686989 cites W2071808034 @default.
- W1555686989 cites W2076211104 @default.
- W1555686989 cites W2076894554 @default.
- W1555686989 cites W2077678165 @default.
- W1555686989 cites W2078890238 @default.
- W1555686989 cites W2078991266 @default.
- W1555686989 cites W2079286004 @default.
- W1555686989 cites W2079590715 @default.
- W1555686989 cites W2080487053 @default.
- W1555686989 cites W2081483657 @default.
- W1555686989 cites W2084188625 @default.
- W1555686989 cites W2086181085 @default.
- W1555686989 cites W2087022458 @default.
- W1555686989 cites W2092877240 @default.
- W1555686989 cites W2093421538 @default.
- W1555686989 cites W2094491870 @default.
- W1555686989 cites W2094836307 @default.
- W1555686989 cites W2095036615 @default.
- W1555686989 cites W2095201441 @default.
- W1555686989 cites W2095563779 @default.
- W1555686989 cites W2096791929 @default.
- W1555686989 cites W2098956752 @default.
- W1555686989 cites W2100584193 @default.
- W1555686989 cites W2103618464 @default.
- W1555686989 cites W2107022380 @default.
- W1555686989 cites W2110887671 @default.
- W1555686989 cites W2117444223 @default.
- W1555686989 cites W2120130577 @default.