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• W1555694039 abstract "Glutamate, the main excitatory neurotransmitter in the central nervous system (CNS), signals through ionotropic receptors (iGluRs), including AMPA, kainate and NMDA receptors, which are glutamate-gated ion channels and regulate rapid responses upon activation, and metabotropic receptors (mGluRs), which evoke slower responses through activation of intracellular transduction cascades. mGluRs are single peptide seven-transmembrane spanning proteins linked to intracellular G-proteins although it has been reported that Gprotein-independent signalling can occur (Heuss et al., 1999). Eight different mGluRs (mGluR1–8) have been cloned and classified into three groups (groups I, II and III) based on sequence homology and the intracellular signal transduction pathways they activate. Group I metabotropic glutamate receptors include mGluR1 and mGluR5 subtypes, which activate phospholipase C and induce inositol triphosphate production and intracellular calcium mobilization. Group II mGluRs include mGluR2 and mGluR3 subtypes, whereas Group III mGluRs include mGluR4, mGluR6, mGluR7 and mGluR8 subtypes. All these receptors are negatively coupled to adenylyl cyclase signalling, resulting in inhibition of cyclic AMP production. Since mGluRs are expressed by neurons and glia near the synaptic cleft, where they modulate not only the effect of glutamate on the postsynaptic neurons but also the release of glutamate and other neurotransmitters, it is though that the mGluR system has evolved as a modulating mechanism for controlling excitability into the CNS (Schoepp, 2001). Furthermore, several mGluR subtypes were shown to exert glial and neuro-protective actions in distinct pathological conditions (Bruno et al., 1998; Kingston et al., 1999; D’Onofrio et al., 2001; Ciccarelli et al., 2007; Durand et al., 2010). However, mGluRs have currently received much attention motivated by a strong belief in their potential as drug targets for treatment of anxiety disorders and schizophrenia (Lavreysen & Dautzenberg, 2008; Chaki et al., 2010; Mezler et al., 2010; Schlumberger et al., 2009; Moreno et al., 2009; Patil et al., 2007). The strongest suggestion that mGluRs are not exclusively synaptic receptors derives from numerous studies that demonstrate the presence of functional mGluRs in a number of peripheral non-neuronal cells, many of which do not even originate from the neural crest (Nicoletti et al., 2007), shifting the role of these receptors from mere synaptic regulators to modulators of basic cell functions (such as cell proliferation, differentiation and survival)" @default.
• W1555694039 created "2016-06-24" @default.
• W1555694039 creator A5007484401 @default.
• W1555694039 creator A5045560069 @default.
• W1555694039 creator A5051147421 @default.
• W1555694039 creator A5072846059 @default.
• W1555694039 date "2011-08-01" @default.
• W1555694039 modified "2023-10-18" @default.
• W1555694039 title "Metabotropic Glutamate Receptors in Peripheral Tissues: Implications for Toxicology" @default.
• W1555694039 cites W1481039247 @default.
• W1555694039 cites W1498901682 @default.
• W1555694039 cites W1521612891 @default.
• W1555694039 cites W1550083492 @default.
• W1555694039 cites W1563615702 @default.
• W1555694039 cites W1570554881 @default.
• W1555694039 cites W158127205 @default.
• W1555694039 cites W1601332829 @default.
• W1555694039 cites W1616905455 @default.
• W1555694039 cites W163824121 @default.
• W1555694039 cites W1718302877 @default.
• W1555694039 cites W1835937600 @default.
• W1555694039 cites W1892994595 @default.
• W1555694039 cites W1931173751 @default.
• W1555694039 cites W1935475606 @default.
• W1555694039 cites W1964321405 @default.
• W1555694039 cites W1965488233 @default.
• W1555694039 cites W1967989911 @default.
• W1555694039 cites W1968756429 @default.
• W1555694039 cites W1970231474 @default.
• W1555694039 cites W1972712245 @default.
• W1555694039 cites W1979081340 @default.
• W1555694039 cites W1979523453 @default.
• W1555694039 cites W1981862978 @default.
• W1555694039 cites W1982743776 @default.
• W1555694039 cites W1983454531 @default.
• W1555694039 cites W1988079633 @default.
• W1555694039 cites W1988483132 @default.
• W1555694039 cites W1989582790 @default.
• W1555694039 cites W1990746420 @default.
• W1555694039 cites W1992372546 @default.
• W1555694039 cites W1993857218 @default.
• W1555694039 cites W1997315163 @default.
• W1555694039 cites W2000296915 @default.
• W1555694039 cites W2002625688 @default.
• W1555694039 cites W2003699345 @default.
• W1555694039 cites W2003708984 @default.
• W1555694039 cites W2003772702 @default.
• W1555694039 cites W2004824621 @default.
• W1555694039 cites W2005869702 @default.
• W1555694039 cites W2007633164 @default.
• W1555694039 cites W2009208678 @default.
• W1555694039 cites W2011619507 @default.
• W1555694039 cites W2011767937 @default.
• W1555694039 cites W2014577644 @default.
• W1555694039 cites W2014739886 @default.
• W1555694039 cites W2017208259 @default.
• W1555694039 cites W2017448724 @default.
• W1555694039 cites W2019776798 @default.
• W1555694039 cites W2023168100 @default.
• W1555694039 cites W2023986042 @default.
• W1555694039 cites W2024795810 @default.
• W1555694039 cites W2030147217 @default.
• W1555694039 cites W2031125523 @default.
• W1555694039 cites W2031201091 @default.
• W1555694039 cites W2031370385 @default.
• W1555694039 cites W2032435880 @default.
• W1555694039 cites W2033678540 @default.
• W1555694039 cites W2037069672 @default.
• W1555694039 cites W2039464566 @default.
• W1555694039 cites W2044675637 @default.
• W1555694039 cites W2044762872 @default.
• W1555694039 cites W2046064425 @default.
• W1555694039 cites W2048203983 @default.
• W1555694039 cites W2052190109 @default.
• W1555694039 cites W2053034106 @default.
• W1555694039 cites W2053245102 @default.
• W1555694039 cites W2057331892 @default.
• W1555694039 cites W2058305638 @default.
• W1555694039 cites W2058381559 @default.
• W1555694039 cites W2060367057 @default.
• W1555694039 cites W2062998121 @default.
• W1555694039 cites W2063904450 @default.
• W1555694039 cites W2066564897 @default.
• W1555694039 cites W2069012347 @default.
• W1555694039 cites W2070437253 @default.
• W1555694039 cites W2073347086 @default.
• W1555694039 cites W2074772639 @default.
• W1555694039 cites W2077944067 @default.
• W1555694039 cites W2079055970 @default.
• W1555694039 cites W2080779966 @default.
• W1555694039 cites W2081880248 @default.
• W1555694039 cites W2084385144 @default.
• W1555694039 cites W2089939109 @default.
• W1555694039 cites W2090216157 @default.
• W1555694039 cites W2090313936 @default.
• W1555694039 cites W2090327651 @default.
• W1555694039 cites W2092235107 @default.
• W1555694039 cites W2092477459 @default.
• W1555694039 cites W2093381843 @default.
• W1555694039 cites W2097573588 @default.

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