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• W1555843904 abstract "The novel genetic information gained from genome-wide high throughput techniques has greatly improved our understanding of peripheral T-cell lymphoma (PTCL). PTCL consists of numerous distinct entities and is currently diagnosed using a combination of clinical and morphologic features and immunophenotyping together with limited molecular assays leading to an often fragmented, complicated diagnostic system. The diagnosis of many cases is challenging even for expert hematopathologists and more than a third of the cases cannot be further classified and thus put into the PTCL–NOS category. Gene expression profiling (GEP) has significantly improved the molecular classification of PTCLs and identified robust molecular signatures for common nodal subtypes of PTCL including angioimmunoblastic T-cell lymphoma (AITL), anaplastic T-cell lymphoma (ALCL), adult T-cell leukemia/lymphoma (ATLL) and extra-nodal NK/T cell lymphoma (ENKTL). These studies also led to identification of novel molecular subtypes with distinct prognosis, that otherwise could not be identified by conventional methods. Integration of massive sequencing strategies and gene expression has characterized driver genetic alterations in common subtypes like AITL, ALCL, ENKTL and other PTCLs. These studies have identified oncogenic pathways and genes affected in specific disease subtypes that can be potentially targeted by specific therapies. Novel treatment options with FDA approved drugs directed towards mutant IDH2, the NF-κB, JAK/STAT, or mTOR pathways illustrate the usefulness of genome-wide techniques to identify targets for therapy. In this review, we highlight recent advances in the molecular diagnosis and prognosis of PTCL using these genome-wide techniques." @default.
• W1555843904 created "2016-06-24" @default.
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• W1555843904 date "2016-03-01" @default.
• W1555843904 modified "2023-10-18" @default.
• W1555843904 title "Genomic signatures in T-cell lymphoma: How can these improve precision in diagnosis and inform prognosis?" @default.
• W1555843904 cites W1587476434 @default.
• W1555843904 cites W1596304334 @default.
• W1555843904 cites W1968235930 @default.
• W1555843904 cites W1976564639 @default.
• W1555843904 cites W1977198374 @default.
• W1555843904 cites W1978886141 @default.
• W1555843904 cites W1979925584 @default.
• W1555843904 cites W1981715054 @default.
• W1555843904 cites W1983084203 @default.
• W1555843904 cites W1983559722 @default.
• W1555843904 cites W1986954124 @default.
• W1555843904 cites W1988703453 @default.
• W1555843904 cites W1992099424 @default.
• W1555843904 cites W1995314727 @default.
• W1555843904 cites W1999103120 @default.
• W1555843904 cites W1999637438 @default.
• W1555843904 cites W2004173971 @default.
• W1555843904 cites W2015684600 @default.
• W1555843904 cites W2016783244 @default.
• W1555843904 cites W2019181493 @default.
• W1555843904 cites W2020976121 @default.
• W1555843904 cites W2021247755 @default.
• W1555843904 cites W2023014046 @default.
• W1555843904 cites W2023169579 @default.
• W1555843904 cites W2025444538 @default.
• W1555843904 cites W2026702457 @default.
• W1555843904 cites W2027564190 @default.
• W1555843904 cites W2029854218 @default.
• W1555843904 cites W2032713012 @default.
• W1555843904 cites W2033522935 @default.
• W1555843904 cites W2034851497 @default.
• W1555843904 cites W2035086577 @default.
• W1555843904 cites W2035788340 @default.
• W1555843904 cites W2036242721 @default.
• W1555843904 cites W2037796411 @default.
• W1555843904 cites W2038586807 @default.
• W1555843904 cites W2041598067 @default.
• W1555843904 cites W2050908246 @default.
• W1555843904 cites W2058194048 @default.
• W1555843904 cites W2058451329 @default.
• W1555843904 cites W2058505119 @default.
• W1555843904 cites W2058584439 @default.
• W1555843904 cites W2058686342 @default.
• W1555843904 cites W2061680337 @default.
• W1555843904 cites W2066872359 @default.
• W1555843904 cites W2067999861 @default.
• W1555843904 cites W2068478831 @default.
• W1555843904 cites W2069271377 @default.
• W1555843904 cites W2069421122 @default.
• W1555843904 cites W2073504536 @default.
• W1555843904 cites W2074525507 @default.
• W1555843904 cites W2074678620 @default.
• W1555843904 cites W2075117946 @default.
• W1555843904 cites W2078089821 @default.
• W1555843904 cites W2079116568 @default.
• W1555843904 cites W2085180155 @default.
• W1555843904 cites W2088636620 @default.
• W1555843904 cites W2091572955 @default.
• W1555843904 cites W2092048234 @default.
• W1555843904 cites W2100162337 @default.
• W1555843904 cites W2100163251 @default.
• W1555843904 cites W2111500154 @default.
• W1555843904 cites W2116068882 @default.
• W1555843904 cites W2120566462 @default.
• W1555843904 cites W2123807140 @default.
• W1555843904 cites W2124482385 @default.
• W1555843904 cites W2125847997 @default.
• W1555843904 cites W2127159379 @default.
• W1555843904 cites W2127304877 @default.
• W1555843904 cites W2131626628 @default.
• W1555843904 cites W2131778748 @default.
• W1555843904 cites W2131860315 @default.
• W1555843904 cites W2132598458 @default.
• W1555843904 cites W2136426653 @default.
• W1555843904 cites W2139891818 @default.
• W1555843904 cites W2141453917 @default.
• W1555843904 cites W2142828330 @default.
• W1555843904 cites W2144566097 @default.
• W1555843904 cites W2145534945 @default.
• W1555843904 cites W2146112074 @default.
• W1555843904 cites W2146146853 @default.
• W1555843904 cites W2147246240 @default.
• W1555843904 cites W2150382709 @default.

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