Matches in SemOpenAlex for { <https://semopenalex.org/work/W1555888928> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W1555888928 endingPage "406" @default.
- W1555888928 startingPage "399" @default.
- W1555888928 abstract "Archival tissues are a bountiful resource for various studies. Polymerase chain reaction permits the use of such tissues for molecular biological analyses of disease causation. However, a comprehensive study using a large number of decades-old samples (20 or more years) for molecular oncology/epidemiology has never been shown to be feasible. We have relied upon the unique tumor registry of atomic bomb survivors to show that such studies are possible using 275 hepatocellular carcinoma and 41 skin cancer cases. We used 23 relatively recent thyroid papillary carcinoma cases from persons living in the vicinity of the Chernobyl nuclear reactor accident for comparison. Degradation of DNA is severe in autopsy hepatocellular carcinoma samples but can be compensated for by decreasing the polymerase chain reaction product size. Increasing the amount of DNA that is used by a factor of 8 improved amplification efficiency from approximately 60 to 80%. Age of the samples was not as great a problem as was the source of procurement. The extracted DNA can be used for all types of assays that require polymerase chain reaction amplification, such as restriction fragment length polymorphism, single-strand conformation polymorphism, and direct sequencing." @default.
- W1555888928 created "2016-06-24" @default.
- W1555888928 creator A5002299491 @default.
- W1555888928 creator A5012291537 @default.
- W1555888928 creator A5018888082 @default.
- W1555888928 creator A5038743598 @default.
- W1555888928 creator A5053939485 @default.
- W1555888928 creator A5059130328 @default.
- W1555888928 creator A5069711734 @default.
- W1555888928 date "1996-08-01" @default.
- W1555888928 modified "2023-09-23" @default.
- W1555888928 title "Feasibility of using decades-old archival tissues in molecular oncology/epidemiology." @default.
- W1555888928 cites W1505025572 @default.
- W1555888928 cites W1965058394 @default.
- W1555888928 cites W1975814727 @default.
- W1555888928 cites W1975993620 @default.
- W1555888928 cites W1989349801 @default.
- W1555888928 cites W1990278325 @default.
- W1555888928 cites W2001923549 @default.
- W1555888928 cites W2022213176 @default.
- W1555888928 cites W2030810311 @default.
- W1555888928 cites W2035931368 @default.
- W1555888928 cites W2062587785 @default.
- W1555888928 cites W2079732194 @default.
- W1555888928 cites W2085902087 @default.
- W1555888928 cites W2094863625 @default.
- W1555888928 cites W2110221107 @default.
- W1555888928 cites W2123944316 @default.
- W1555888928 cites W2128879096 @default.
- W1555888928 cites W2142594224 @default.
- W1555888928 cites W2372467570 @default.
- W1555888928 cites W88553194 @default.
- W1555888928 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1865296" @default.
- W1555888928 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8701980" @default.
- W1555888928 hasPublicationYear "1996" @default.
- W1555888928 type Work @default.
- W1555888928 sameAs 1555888928 @default.
- W1555888928 citedByCount "17" @default.
- W1555888928 countsByYear W15558889282013 @default.
- W1555888928 countsByYear W15558889282015 @default.
- W1555888928 countsByYear W15558889282016 @default.
- W1555888928 countsByYear W15558889282017 @default.
- W1555888928 countsByYear W15558889282018 @default.
- W1555888928 countsByYear W15558889282022 @default.
- W1555888928 crossrefType "journal-article" @default.
- W1555888928 hasAuthorship W1555888928A5002299491 @default.
- W1555888928 hasAuthorship W1555888928A5012291537 @default.
- W1555888928 hasAuthorship W1555888928A5018888082 @default.
- W1555888928 hasAuthorship W1555888928A5038743598 @default.
- W1555888928 hasAuthorship W1555888928A5053939485 @default.
- W1555888928 hasAuthorship W1555888928A5059130328 @default.
- W1555888928 hasAuthorship W1555888928A5069711734 @default.
- W1555888928 hasConcept C104317684 @default.
- W1555888928 hasConcept C107130276 @default.
- W1555888928 hasConcept C142724271 @default.
- W1555888928 hasConcept C143998085 @default.
- W1555888928 hasConcept C2778019345 @default.
- W1555888928 hasConcept C49105822 @default.
- W1555888928 hasConcept C54355233 @default.
- W1555888928 hasConcept C71924100 @default.
- W1555888928 hasConcept C86803240 @default.
- W1555888928 hasConceptScore W1555888928C104317684 @default.
- W1555888928 hasConceptScore W1555888928C107130276 @default.
- W1555888928 hasConceptScore W1555888928C142724271 @default.
- W1555888928 hasConceptScore W1555888928C143998085 @default.
- W1555888928 hasConceptScore W1555888928C2778019345 @default.
- W1555888928 hasConceptScore W1555888928C49105822 @default.
- W1555888928 hasConceptScore W1555888928C54355233 @default.
- W1555888928 hasConceptScore W1555888928C71924100 @default.
- W1555888928 hasConceptScore W1555888928C86803240 @default.
- W1555888928 hasIssue "2" @default.
- W1555888928 hasLocation W15558889281 @default.
- W1555888928 hasOpenAccess W1555888928 @default.
- W1555888928 hasPrimaryLocation W15558889281 @default.
- W1555888928 hasRelatedWork W2016596724 @default.
- W1555888928 hasRelatedWork W2033489395 @default.
- W1555888928 hasRelatedWork W2037373396 @default.
- W1555888928 hasRelatedWork W2134558634 @default.
- W1555888928 hasRelatedWork W2144936227 @default.
- W1555888928 hasRelatedWork W2367783732 @default.
- W1555888928 hasRelatedWork W2973064213 @default.
- W1555888928 hasRelatedWork W3018873590 @default.
- W1555888928 hasRelatedWork W3091367366 @default.
- W1555888928 hasRelatedWork W4240236077 @default.
- W1555888928 hasVolume "149" @default.
- W1555888928 isParatext "false" @default.
- W1555888928 isRetracted "false" @default.
- W1555888928 magId "1555888928" @default.
- W1555888928 workType "article" @default.