FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1555892706> ?p ?o ?g. }

• W1555892706 abstract "To explore the role of smoking in breast cancer, we undertook a population-based study to evaluate the prevalence and spectrum of p53 mutations in the breast tumors of smokers and nonsmokers. We evaluated 456 archival invasive breast tumors for mutations in exons 4-8 of the p53 gene, using single-strand conformational polymorphism analysis and manual sequencing. Statistical analyses were performed to determine the association of p53 mutations with clinical and smoking characteristics. Of 108 mutations identified, 77 (71%) were point mutations and 31 (29%) were deletions or insertions. A higher prevalence of p53 mutations was found in the breast tumors of current smokers (36.5%; P = 0.02) compared with never smokers (23.6%), whereas fewer mutations were found in former smokers (16.2%; P = 0.09). After adjustment for age, race, menopausal status, clinical stage, tumor size, and family history of breast cancer, current smokers were significantly more likely to harbor any p53 mutation [odds ratio (OR), 2.11; 95% confidence interval (CI), 1.17-3.78], p53 transversions (OR, 3.37; 95% CI, 1.03-11.06), and G:C-->T:A transversions (OR, 10.53; 95% CI, 1.77-62.55) compared with never smokers. Stage at diagnosis did not account for the increase in p53 mutation-positive breast cancer among current smokers. Former smokers were also more likely than never smokers to harbor G:C-->T:A transversions (OR, 2.43; 95% CI, 0.37-15.73), although this association was not statistically significant. Among former smokers, the prevalence of p53 mutations varied with time since quitting: former smokers who quit smoking for longer than 1 year had a lower prevalence of p53 mutations (10.5% for 1-5 years and 12.9% for >5 years) than those who had stopped smoking within the year of their cancer diagnosis (26.3%). Our results indicate that cigarette smoking appears to modify the prevalence and spectrum of p53 mutations in breast tumors. Moreover, the difference in mutational spectra observed between smokers and nonsmokers is suggestive of the genotoxic effects of smoking in breast tissue." @default.
• W1555892706 created "2016-06-24" @default.
• W1555892706 creator A5002353139 @default.
• W1555892706 creator A5005961131 @default.
• W1555892706 creator A5010481627 @default.
• W1555892706 creator A5012207888 @default.
• W1555892706 creator A5034228539 @default.
• W1555892706 creator A5036975309 @default.
• W1555892706 creator A5044239203 @default.
• W1555892706 creator A5051670486 @default.
• W1555892706 creator A5070242219 @default.
• W1555892706 creator A5070309472 @default.
• W1555892706 creator A5076660313 @default.
• W1555892706 creator A5087904844 @default.
• W1555892706 date "2002-04-01" @default.
• W1555892706 modified "2023-09-23" @default.
• W1555892706 title "Prevalence and spectrum of p53 mutations associated with smoking in breast cancer" @default.
• W1555892706 hasPublicationYear "2002" @default.
• W1555892706 type Work @default.
• W1555892706 sameAs 1555892706 @default.
• W1555892706 citedByCount "0" @default.
• W1555892706 crossrefType "journal-article" @default.
• W1555892706 hasAuthorship W1555892706A5002353139 @default.
• W1555892706 hasAuthorship W1555892706A5005961131 @default.
• W1555892706 hasAuthorship W1555892706A5010481627 @default.
• W1555892706 hasAuthorship W1555892706A5012207888 @default.
• W1555892706 hasAuthorship W1555892706A5034228539 @default.
• W1555892706 hasAuthorship W1555892706A5036975309 @default.
• W1555892706 hasAuthorship W1555892706A5044239203 @default.
• W1555892706 hasAuthorship W1555892706A5051670486 @default.
• W1555892706 hasAuthorship W1555892706A5070242219 @default.
• W1555892706 hasAuthorship W1555892706A5070309472 @default.
• W1555892706 hasAuthorship W1555892706A5076660313 @default.
• W1555892706 hasAuthorship W1555892706A5087904844 @default.
• W1555892706 hasConcept C121608353 @default.
• W1555892706 hasConcept C126322002 @default.
• W1555892706 hasConcept C143998085 @default.
• W1555892706 hasConcept C156957248 @default.
• W1555892706 hasConcept C44249647 @default.
• W1555892706 hasConcept C530470458 @default.
• W1555892706 hasConcept C71924100 @default.
• W1555892706 hasConceptScore W1555892706C121608353 @default.
• W1555892706 hasConceptScore W1555892706C126322002 @default.
• W1555892706 hasConceptScore W1555892706C143998085 @default.
• W1555892706 hasConceptScore W1555892706C156957248 @default.
• W1555892706 hasConceptScore W1555892706C44249647 @default.
• W1555892706 hasConceptScore W1555892706C530470458 @default.
• W1555892706 hasConceptScore W1555892706C71924100 @default.
• W1555892706 hasLocation W15558927061 @default.
• W1555892706 hasOpenAccess W1555892706 @default.
• W1555892706 hasPrimaryLocation W15558927061 @default.
• W1555892706 hasRelatedWork W1966738726 @default.
• W1555892706 hasRelatedWork W1984717593 @default.
• W1555892706 hasRelatedWork W1998982181 @default.
• W1555892706 hasRelatedWork W2009594867 @default.
• W1555892706 hasRelatedWork W2041318803 @default.
• W1555892706 hasRelatedWork W2059142484 @default.
• W1555892706 hasRelatedWork W2063887812 @default.
• W1555892706 hasRelatedWork W2070320331 @default.
• W1555892706 hasRelatedWork W2073172245 @default.
• W1555892706 hasRelatedWork W2088555055 @default.
• W1555892706 hasRelatedWork W2101569260 @default.
• W1555892706 hasRelatedWork W2108067150 @default.
• W1555892706 hasRelatedWork W2117118711 @default.
• W1555892706 hasRelatedWork W2134175200 @default.
• W1555892706 hasRelatedWork W2141227362 @default.
• W1555892706 hasRelatedWork W2339098759 @default.
• W1555892706 hasRelatedWork W2355663726 @default.
• W1555892706 hasRelatedWork W2584836931 @default.
• W1555892706 hasRelatedWork W2923252099 @default.
• W1555892706 hasRelatedWork W2280545572 @default.
• W1555892706 isParatext "false" @default.
• W1555892706 isRetracted "false" @default.
• W1555892706 magId "1555892706" @default.
• W1555892706 workType "article" @default.