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- W155600552 abstract "Stem cells possess the remarkable property of being able to self-renew and give rise to at least one more differentiated cell type. Embryonic stem cells have the ability to differentiate into all cell types of the body and have unlimited self-renewal potential. Somatic stem cells are found in many adult tissues. They have an extensive but finite life-span and can differentiate into a more restricted range of cell types. Increasing evidence suggests that the multilineage differentiation ability of stem cells is brought about by the potential for expression of developmentally regulated transcription factors and of lineage-specification genes. Potential for gene expression is largely controlled by epigenetic modifications of DNA (DNA methylation) and chromatin (such as post-translational histone modifications) on regulatory regions. These modifications modulate chromatin organization not only on specific genes but also at the level of the whole nucleus. They can also influence the timing of DNA replication. This chapter highlights how epigenetic mechanisms that poise genes for transcription in undifferentiated stem cells are being uncovered through, notably, genome-wide mapping of DNA methylation, histone modifications, and transcription factor binding. Epigenetic marks on developmentally regulated and lineage-specifying genes in undifferentiated stem cells seem to define a pluripotent state." @default.
- W155600552 created "2016-06-24" @default.
- W155600552 creator A5004175128 @default.
- W155600552 creator A5005479598 @default.
- W155600552 creator A5072506531 @default.
- W155600552 date "2009-01-01" @default.
- W155600552 modified "2023-09-25" @default.
- W155600552 title "Epigenetic Basis for Differentiation Plasticity in Stem Cells" @default.
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