FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1556025537> ?p ?o ?g. }

• W1556025537 abstract "Early research into Alzheimer's disease launched the cholinergic hypothesis, based on the correlation between central cholinergic deficiency and clinical measures of cognitive decline. This was epitomized in therapeutic strategies employing a variety of procholinergic agents, of which only the inhibitors of cholinesterase (ChE), the enzyme thai hydrolyzes acetylcholine in the synaptic cleft, have been proven clinically viable. Five such agents are reviewed: tacrine and donepezil, which act at the ionic subsite of acetylcholinesterase (AChE), and rivastigmine, galantamine, and metrifonate, which act at its catalytic esteratic subsite. Despite statistical evidence of efficacy from numerous well-controlled multicenter trials, important clinical utility issues remain outstanding: (i) number-needed-to-treat (NNT) analyses, quantifying the number of patients needing to be treated for one patient to show benefit, find values of 3 to 20; (ii) the pivotal trials themselves were conducted in nonrepreseniative populations, largely comprised of physically healthy outpatients with mildto-moderate Alzheimer's disease and a mean age of 72 years (thereby excluding over 30% of typical Alzheimer patients in State of California-funded clinics), treated for up to 6 months; and (Hi) tolerability is underreported and characterized by a positive correlation between dose, effect and cholinergic side effects - potentially serious adverse events include bradycardia, anorexia, weight loss and myasthenia with respiratory depression. Therapies thus require titration and constant monitoring. Nevertheless, acetylcholinesterase inhibitors (AChEls) constitute the first class of effective agents and are likely to remain so in the continuing absence of viable alternatives." @default.
• W1556025537 created "2016-06-24" @default.
• W1556025537 creator A5059020389 @default.
• W1556025537 date "2000-06-01" @default.
• W1556025537 modified "2023-10-17" @default.
• W1556025537 title "A critical review of cholinesterase inhibitors as a treatment modality in Alzheimer's disease." @default.
• W1556025537 cites W17160253 @default.
• W1556025537 cites W1940008043 @default.
• W1556025537 cites W1968294251 @default.
• W1556025537 cites W1970104807 @default.
• W1556025537 cites W1980525435 @default.
• W1556025537 cites W1985528178 @default.
• W1556025537 cites W1990543766 @default.
• W1556025537 cites W1992741964 @default.
• W1556025537 cites W1994197596 @default.
• W1556025537 cites W1994534571 @default.
• W1556025537 cites W2000837493 @default.
• W1556025537 cites W2004713321 @default.
• W1556025537 cites W2006734683 @default.
• W1556025537 cites W2007158999 @default.
• W1556025537 cites W2010456038 @default.
• W1556025537 cites W2013960149 @default.
• W1556025537 cites W2016659621 @default.
• W1556025537 cites W2016958718 @default.
• W1556025537 cites W2025281969 @default.
• W1556025537 cites W2026145994 @default.
• W1556025537 cites W2028843740 @default.
• W1556025537 cites W2036736649 @default.
• W1556025537 cites W2036898214 @default.
• W1556025537 cites W2041242231 @default.
• W1556025537 cites W2044358931 @default.
• W1556025537 cites W2050876413 @default.
• W1556025537 cites W2055727638 @default.
• W1556025537 cites W2057679568 @default.
• W1556025537 cites W2065052203 @default.
• W1556025537 cites W2069284334 @default.
• W1556025537 cites W2075506578 @default.
• W1556025537 cites W2080488285 @default.
• W1556025537 cites W2081285591 @default.
• W1556025537 cites W2084107396 @default.
• W1556025537 cites W2093018325 @default.
• W1556025537 cites W2093216480 @default.
• W1556025537 cites W2093750177 @default.
• W1556025537 cites W2095451153 @default.
• W1556025537 cites W2096666059 @default.
• W1556025537 cites W2098999434 @default.
• W1556025537 cites W2117134611 @default.
• W1556025537 cites W2122692162 @default.
• W1556025537 cites W2125993125 @default.
• W1556025537 cites W2130992306 @default.
• W1556025537 cites W2155087576 @default.
• W1556025537 cites W2168210393 @default.
• W1556025537 cites W2168516263 @default.
• W1556025537 cites W2172216689 @default.
• W1556025537 cites W2237008908 @default.
• W1556025537 cites W2397224240 @default.
• W1556025537 cites W2402796403 @default.
• W1556025537 cites W2406286951 @default.
• W1556025537 cites W2413471910 @default.
• W1556025537 cites W3216169949 @default.
• W1556025537 cites W1599716179 @default.
• W1556025537 cites W1987621030 @default.
• W1556025537 cites W3021807135 @default.
• W1556025537 cites W3186393085 @default.
• W1556025537 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3181592" @default.
• W1556025537 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22033801" @default.
• W1556025537 hasPublicationYear "2000" @default.
• W1556025537 type Work @default.
• W1556025537 sameAs 1556025537 @default.
• W1556025537 citedByCount "22" @default.
• W1556025537 countsByYear W15560255372013 @default.
• W1556025537 countsByYear W15560255372014 @default.
• W1556025537 countsByYear W15560255372016 @default.
• W1556025537 countsByYear W15560255372017 @default.
• W1556025537 countsByYear W15560255372018 @default.
• W1556025537 countsByYear W15560255372019 @default.
• W1556025537 countsByYear W15560255372021 @default.
• W1556025537 countsByYear W15560255372022 @default.
• W1556025537 countsByYear W15560255372023 @default.
• W1556025537 crossrefType "journal-article" @default.
• W1556025537 hasAuthorship W1556025537A5059020389 @default.
• W1556025537 hasConcept C126322002 @default.
• W1556025537 hasConcept C181199279 @default.
• W1556025537 hasConcept C185592680 @default.
• W1556025537 hasConcept C197934379 @default.
• W1556025537 hasConcept C22885893 @default.
• W1556025537 hasConcept C2776332859 @default.
• W1556025537 hasConcept C2778375690 @default.
• W1556025537 hasConcept C2778816929 @default.
• W1556025537 hasConcept C2779046751 @default.
• W1556025537 hasConcept C2779056891 @default.
• W1556025537 hasConcept C2779134260 @default.
• W1556025537 hasConcept C2779483572 @default.
• W1556025537 hasConcept C2780904820 @default.
• W1556025537 hasConcept C31896038 @default.
• W1556025537 hasConcept C502032728 @default.
• W1556025537 hasConcept C535046627 @default.
• W1556025537 hasConcept C55493867 @default.
• W1556025537 hasConcept C71924100 @default.
• W1556025537 hasConcept C98274493 @default.

• next