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- W1556087983 abstract "The paper by Jelinek and colleagues1 in this issue examines the short-term immunogenicity of an accelerated Vero cell-derived Japanese encephalitis vaccine (JE-VC) regimen administered at Days 1 and 8. This regimen is compared with the conventional Days 1 and 29 administration schedule;2 this latter interval frustrates many pre-travel advisors who well know of the high proportion of travelers presenting in close proximity to departure.In an increasingly fast-paced world, this study addresses part of a long-standing larger desire to prepare all travelers for their trips if there is only a week to do so prior to departure. With much of the adult population in many countries already immunized against hepatitis B,3 the remaining usual travel vaccines that require more than a single dose are then restricted to Japanese encephalitis and rabies.It is a well-established principle of vaccinology that once you find an appropriate vaccine antigen and if you administer a large quantity of antigen in a single dose or multiple doses very quickly, you will get an antibody response, and often at very high-titers, very rapidly.4,5 The issue then becomes how long that antibody response will last at protective levels. Conventional vaccine regimens are typically designed to give a durable antibody response, ideally for life, or at least for an interval of several years before boosting is required. … Corresponding Author: David O. Freedman, MD, W.C. Gorgas Center for Geographic Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, 845 19th St. S. #203, Birmingham, AL 35294-2170, USA. E-mail: dfreedman{at}shoreland.com" @default.
- W1556087983 created "2016-06-24" @default.
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- W1556087983 date "2015-07-01" @default.
- W1556087983 modified "2023-09-27" @default.
- W1556087983 title "Imminent Departures: Rapid Vaccination Strategies Designed to Induce Short-Term Immunogenicity for the Trip at Hand" @default.
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- W1556087983 doi "https://doi.org/10.1111/jtm.12199" @default.
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