Matches in SemOpenAlex for { <https://semopenalex.org/work/W1556134345> ?p ?o ?g. }
- W1556134345 endingPage "5546" @default.
- W1556134345 startingPage "5535" @default.
- W1556134345 abstract "Cancer cells display enhanced glycolysis to meet their energetic and biosynthetic demands even under normal oxygen concentrations. Recent studies have revealed that tumor suppressor p53 represses glycolysis under normoxia as a novel mechanism for tumor suppression. As a common microenvironmental stress for tumors, hypoxia drives the metabolic switch from the oxidative phosphorylation to glycolysis, which is crucial for survival and proliferation of cancer cells under hypoxia. The p53's role and mechanism in regulating glycolysis under hypoxia is poorly understood. Here, we found that p53 represses hypoxia-stimulated glycolysis in cancer cells through RRAD, a newly-identified p53 target. RRAD expression is frequently decreased in lung cancer. Ectopic expression of RRAD greatly reduces glycolysis whereas knockdown of RRAD promotes glycolysis in lung cancer cells. Furthermore, RRAD represses glycolysis mainly through inhibition of GLUT1 translocation to the plasma membrane. Under hypoxic conditions, p53 induces RRAD, which in turn inhibits the translocation of GLUT1 and represses glycolysis in lung cancer cells. Blocking RRAD by siRNA greatly abolishes p53's function in repressing glycolysis under hypoxia. Taken together, our results revealed an important role and mechanism of p53 in antagonizing the stimulating effect of hypoxia on glycolysis, which contributes to p53's function in tumor suppression." @default.
- W1556134345 created "2016-06-24" @default.
- W1556134345 creator A5017058735 @default.
- W1556134345 creator A5032870549 @default.
- W1556134345 creator A5044463543 @default.
- W1556134345 creator A5051771989 @default.
- W1556134345 creator A5057117256 @default.
- W1556134345 creator A5066337255 @default.
- W1556134345 creator A5067949841 @default.
- W1556134345 creator A5080125836 @default.
- W1556134345 creator A5089414696 @default.
- W1556134345 date "2014-06-26" @default.
- W1556134345 modified "2023-09-23" @default.
- W1556134345 title "Tumor suppressor p53 negatively regulates glycolysis stimulated by hypoxia through its target RRAD" @default.
- W1556134345 cites W1645918562 @default.
- W1556134345 cites W1966163762 @default.
- W1556134345 cites W1971859682 @default.
- W1556134345 cites W1979159394 @default.
- W1556134345 cites W1988733824 @default.
- W1556134345 cites W1990948801 @default.
- W1556134345 cites W1991510903 @default.
- W1556134345 cites W1991752891 @default.
- W1556134345 cites W1996507796 @default.
- W1556134345 cites W1997427652 @default.
- W1556134345 cites W2015207840 @default.
- W1556134345 cites W2015726140 @default.
- W1556134345 cites W2025722611 @default.
- W1556134345 cites W2028897202 @default.
- W1556134345 cites W2035608099 @default.
- W1556134345 cites W2038652783 @default.
- W1556134345 cites W2059109318 @default.
- W1556134345 cites W2062515127 @default.
- W1556134345 cites W2067265392 @default.
- W1556134345 cites W2069448970 @default.
- W1556134345 cites W2071734535 @default.
- W1556134345 cites W2072451938 @default.
- W1556134345 cites W2074542266 @default.
- W1556134345 cites W2074820129 @default.
- W1556134345 cites W2080245613 @default.
- W1556134345 cites W2092627144 @default.
- W1556134345 cites W2095916340 @default.
- W1556134345 cites W2098974443 @default.
- W1556134345 cites W2119239003 @default.
- W1556134345 cites W2125547155 @default.
- W1556134345 cites W2130503287 @default.
- W1556134345 cites W2131224845 @default.
- W1556134345 cites W2133959309 @default.
- W1556134345 cites W2149828028 @default.
- W1556134345 cites W2154115500 @default.
- W1556134345 cites W2155279237 @default.
- W1556134345 cites W2157446482 @default.
- W1556134345 cites W2160328993 @default.
- W1556134345 cites W2166268973 @default.
- W1556134345 cites W2170920268 @default.
- W1556134345 doi "https://doi.org/10.18632/oncotarget.2137" @default.
- W1556134345 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4170611" @default.
- W1556134345 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25114038" @default.
- W1556134345 hasPublicationYear "2014" @default.
- W1556134345 type Work @default.
- W1556134345 sameAs 1556134345 @default.
- W1556134345 citedByCount "77" @default.
- W1556134345 countsByYear W15561343452014 @default.
- W1556134345 countsByYear W15561343452015 @default.
- W1556134345 countsByYear W15561343452016 @default.
- W1556134345 countsByYear W15561343452017 @default.
- W1556134345 countsByYear W15561343452018 @default.
- W1556134345 countsByYear W15561343452019 @default.
- W1556134345 countsByYear W15561343452020 @default.
- W1556134345 countsByYear W15561343452021 @default.
- W1556134345 countsByYear W15561343452022 @default.
- W1556134345 countsByYear W15561343452023 @default.
- W1556134345 crossrefType "journal-article" @default.
- W1556134345 hasAuthorship W1556134345A5017058735 @default.
- W1556134345 hasAuthorship W1556134345A5032870549 @default.
- W1556134345 hasAuthorship W1556134345A5044463543 @default.
- W1556134345 hasAuthorship W1556134345A5051771989 @default.
- W1556134345 hasAuthorship W1556134345A5057117256 @default.
- W1556134345 hasAuthorship W1556134345A5066337255 @default.
- W1556134345 hasAuthorship W1556134345A5067949841 @default.
- W1556134345 hasAuthorship W1556134345A5080125836 @default.
- W1556134345 hasAuthorship W1556134345A5089414696 @default.
- W1556134345 hasBestOaLocation W15561343451 @default.
- W1556134345 hasConcept C121608353 @default.
- W1556134345 hasConcept C134018914 @default.
- W1556134345 hasConcept C161573976 @default.
- W1556134345 hasConcept C173396325 @default.
- W1556134345 hasConcept C178790620 @default.
- W1556134345 hasConcept C185592680 @default.
- W1556134345 hasConcept C190283241 @default.
- W1556134345 hasConcept C20251656 @default.
- W1556134345 hasConcept C2777952866 @default.
- W1556134345 hasConcept C2779306644 @default.
- W1556134345 hasConcept C502942594 @default.
- W1556134345 hasConcept C540031477 @default.
- W1556134345 hasConcept C54355233 @default.
- W1556134345 hasConcept C55493867 @default.
- W1556134345 hasConcept C55885012 @default.
- W1556134345 hasConcept C57600042 @default.