FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1556217440> ?p ?o ?g. }

• W1556217440 endingPage "1756" @default.
• W1556217440 startingPage "1748" @default.
• W1556217440 abstract "Growing evidence suggests that long-term abuse of ketamine does harm the heart and increases the risk of sudden death. The present study was performed to explore the cardiotoxicity of ketamine and the protective effects of metoprolol.Rats and rabbits were divided into control, ketamine, metoprolol alone and ketamine plus metoprolol groups. Ketamine (40 mg·kg(-1) ·day(-1), i.p.) and metoprolol (20 mg·kg(-1) ·day(-1), p.o.) were administered continuously for 12 weeks in rats and 8 weeks in rabbits. Cardiac function, electrophysiological disturbances, cardiac collagen, cardiomyocte apoptosis and the remodelling-related proteins were evaluated.Rabbits treated with ketamine showed decreased left ventricular ejection fraction, slowed ventricular conduction velocity and increased susceptibility to ventricular arrhythmia. Metoprolol prevented these pathophysiological alterations. In ketamine-treated rats, cardiac collagen volume fraction and apoptotic cell number were higher than those of control animals; these effects were prevented by co-administration of metoprolol. Consistently, the expressions of poly (ADP-ribose) polymerases-1, apoptosis-inducing factor and NF-κB-light-chain-enhancer of activated B cells were all increased after ketamine treatment and sharply reduced after metoprolol administration. Moreover, ketamine enhanced sympathetic sprouting, manifested as increased growth-associated protein 43 and tyrosine TH expression. These effects of ketamine were prevented by metoprolol.Chronic treatment with ketamine caused significant ventricular myocardial apoptosis, fibrosis and sympathetic sprouting, which altered the electrophysiological properties of the heart and increased its susceptibility to malignant arrhythmia that may lead to sudden cardiac death. Metoprolol prevented the cardiotoxicity of ketamine, indicating a promising new therapeutic strategy." @default.
• W1556217440 created "2016-06-24" @default.
• W1556217440 creator A5005239276 @default.
• W1556217440 creator A5009668250 @default.
• W1556217440 creator A5016409571 @default.
• W1556217440 creator A5032758344 @default.
• W1556217440 creator A5039813352 @default.
• W1556217440 creator A5047019838 @default.
• W1556217440 creator A5049775534 @default.
• W1556217440 creator A5053684568 @default.
• W1556217440 creator A5057861736 @default.
• W1556217440 creator A5059058103 @default.
• W1556217440 creator A5060332758 @default.
• W1556217440 creator A5071912145 @default.
• W1556217440 creator A5085640575 @default.
• W1556217440 creator A5087625703 @default.
• W1556217440 creator A5090042356 @default.
• W1556217440 date "2012-02-22" @default.
• W1556217440 modified "2023-09-26" @default.
• W1556217440 title "Ketamine-induced ventricular structural, sympathetic and electrophysiological remodelling: pathological consequences and protective effects of metoprolol" @default.
• W1556217440 cites W1550949102 @default.
• W1556217440 cites W1922824844 @default.
• W1556217440 cites W1980338308 @default.
• W1556217440 cites W1999473143 @default.
• W1556217440 cites W2006445816 @default.
• W1556217440 cites W2011122589 @default.
• W1556217440 cites W2012449838 @default.
• W1556217440 cites W2055335743 @default.
• W1556217440 cites W2060321052 @default.
• W1556217440 cites W2061689246 @default.
• W1556217440 cites W2069380892 @default.
• W1556217440 cites W2073649616 @default.
• W1556217440 cites W2076651820 @default.
• W1556217440 cites W2083106359 @default.
• W1556217440 cites W2091266677 @default.
• W1556217440 cites W2094205173 @default.
• W1556217440 cites W2121082164 @default.
• W1556217440 cites W2125322044 @default.
• W1556217440 cites W2132262439 @default.
• W1556217440 cites W2148532515 @default.
• W1556217440 cites W2152833770 @default.
• W1556217440 cites W2155362097 @default.
• W1556217440 cites W2156177514 @default.
• W1556217440 cites W2160780808 @default.
• W1556217440 cites W2164900394 @default.
• W1556217440 cites W2339609839 @default.
• W1556217440 cites W350300330 @default.
• W1556217440 doi "https://doi.org/10.1111/j.1476-5381.2011.01635.x" @default.
• W1556217440 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3372827" @default.
• W1556217440 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21883145" @default.
• W1556217440 hasPublicationYear "2012" @default.
• W1556217440 type Work @default.
• W1556217440 sameAs 1556217440 @default.
• W1556217440 citedByCount "46" @default.
• W1556217440 countsByYear W15562174402012 @default.
• W1556217440 countsByYear W15562174402013 @default.
• W1556217440 countsByYear W15562174402014 @default.
• W1556217440 countsByYear W15562174402015 @default.
• W1556217440 countsByYear W15562174402016 @default.
• W1556217440 countsByYear W15562174402017 @default.
• W1556217440 countsByYear W15562174402018 @default.
• W1556217440 countsByYear W15562174402019 @default.
• W1556217440 countsByYear W15562174402020 @default.
• W1556217440 countsByYear W15562174402021 @default.
• W1556217440 countsByYear W15562174402022 @default.
• W1556217440 countsByYear W15562174402023 @default.
• W1556217440 crossrefType "journal-article" @default.
• W1556217440 hasAuthorship W1556217440A5005239276 @default.
• W1556217440 hasAuthorship W1556217440A5009668250 @default.
• W1556217440 hasAuthorship W1556217440A5016409571 @default.
• W1556217440 hasAuthorship W1556217440A5032758344 @default.
• W1556217440 hasAuthorship W1556217440A5039813352 @default.
• W1556217440 hasAuthorship W1556217440A5047019838 @default.
• W1556217440 hasAuthorship W1556217440A5049775534 @default.
• W1556217440 hasAuthorship W1556217440A5053684568 @default.
• W1556217440 hasAuthorship W1556217440A5057861736 @default.
• W1556217440 hasAuthorship W1556217440A5059058103 @default.
• W1556217440 hasAuthorship W1556217440A5060332758 @default.
• W1556217440 hasAuthorship W1556217440A5071912145 @default.
• W1556217440 hasAuthorship W1556217440A5085640575 @default.
• W1556217440 hasAuthorship W1556217440A5087625703 @default.
• W1556217440 hasAuthorship W1556217440A5090042356 @default.
• W1556217440 hasBestOaLocation W15562174402 @default.
• W1556217440 hasConcept C126322002 @default.
• W1556217440 hasConcept C134018914 @default.
• W1556217440 hasConcept C164705383 @default.
• W1556217440 hasConcept C2778233292 @default.
• W1556217440 hasConcept C2780795376 @default.
• W1556217440 hasConcept C2781280847 @default.
• W1556217440 hasConcept C29730261 @default.
• W1556217440 hasConcept C42219234 @default.
• W1556217440 hasConcept C71924100 @default.
• W1556217440 hasConcept C98274493 @default.
• W1556217440 hasConceptScore W1556217440C126322002 @default.
• W1556217440 hasConceptScore W1556217440C134018914 @default.
• W1556217440 hasConceptScore W1556217440C164705383 @default.
• W1556217440 hasConceptScore W1556217440C2778233292 @default.
• W1556217440 hasConceptScore W1556217440C2780795376 @default.

• next