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- W1556233496 abstract "Low-flow mediated constriction (L-FMC) is a measure of vascular function complementary to flow-mediated dilation (FMD). L-FMC is commonly observed in the radial artery, however its presence in the brachial artery is equivocal. Furthermore, the effects of age and an acute cardiovascular stress on L-FMC are unknown. We measured brachial L-FMC and FMD (% change) during and following 5-min of distal forearm occlusion in healthy young (n=7; 29±6 years [mean ± SD]) and old (n=5; 64±5 years) women before and after acute isometric handgrip exercise (IHG; 4, 2-min unilateral contractions, each separated by 4-min of rest, at 30% maximal voluntary contraction). Baseline L-FMC and FMD were similar between groups (Both P>0.05). Acute IHG increased FMD in young (6.7±2.2% to 10.4±3.9%, P<0.05), but not old (7.3±5.4% to 9.7±9.6%, P>0.05) women, while L-FMC was unchanged (P>0.05) in both groups (young: -3.5±6.3% to -3.7±4.5%; old: -5.5±9.5% to -4.0±9.0%). In young women, brachial L-FMC and FMD were correlated before (r = 0.90; P<0.05) and after IHG (r = 0.97; P<0.05). In older women, L-FMC and FMD were unrelated before (r = -0.20; P=0.74) but trended towards a correlation after IHG (r = 0.82; P=0.09). In conclusion, L-FMC is observed in the brachial artery of healthy young and old women. Acute IHG appears to restore the relationship between constriction and dilation in old women. Grant Funding Source: Supported by the University of Windsor" @default.
- W1556233496 created "2016-06-24" @default.
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- W1556233496 date "2014-04-01" @default.
- W1556233496 modified "2023-09-27" @default.
- W1556233496 title "Brachial artery flow‐mediated constriction and dilation in response to a cardiovascular stress: potential influence of age (LB683)" @default.
- W1556233496 doi "https://doi.org/10.1096/fasebj.28.1_supplement.lb683" @default.
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