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- W1556359813 abstract "This chapter discusses the evidence that active metabolites of vitamin A (retinoids) and related hormonal signals act as morphogens during the early vertebrate development. It then concentrates on their potential functions in patterning the early vertebrate central nervous system (CNS). The teratogenic effects of acidic retinoids show resemblance to the action of the neural transformation signal, but also differ from this in retinoids that are particularly active in transforming within the fore/mid/hindbrain part of the CNS rather than the spinal cord. An involvement of retinoids in patterning the more anterior part of the CNS is supported, by the results of loss of function experiments, and elements of a potential mechanism are provided, by the identification of RAREs regulating 3′(hindbrain-expressed) hox genes. It is likely that retinoids cooperate, with other pathways, to pattern the whole neural plate. The identification of active acidic retinoids provides candidates for putative retinoid morphogens mediating neural transformation. Hox gene-mediated modulation of the dorsoventral program of growth and neurogenesis provides an elegant mechanism, whereby retinoids and other signals could affect or generate positional information." @default.
- W1556359813 created "2016-06-24" @default.
- W1556359813 creator A5055523716 @default.
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- W1556359813 creator A5075474820 @default.
- W1556359813 creator A5090920078 @default.
- W1556359813 date "1998-01-01" @default.
- W1556359813 modified "2023-09-23" @default.
- W1556359813 title "4 Retinoids and Related Signals in Early Development of the Vertebrate Central Nervous System" @default.
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