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- W1556441133 abstract "Hypodontia is the congenitalabsence of one to six deciduousandJor permanent teeth. This isone of the most frequent altera-tions of the human dentitIon.Although it does not represent aproblem of public health, it maycause masticatory and speechdysfunctions, as well as estheticproblems. Recent studies haveshowed that mutations in the geneMsxl are associatedwith hypodon-tia of second premolars and thirdmolars in humans. The proteinBMP-4 has been identified as aninductive sign ofthe epithelium inthe formation of the teeth. It isproduced in the dental epitheliumwhere it regulates the expressionof genes directly involved in toothmorphogenesis. The aim of thisstudy was to investigate thepresence of polymorphism in theBMP-4 gene promoting region inindividuals with isolated forms ofdental agenesia. Genomic DNAwas obtained from buccal epithe-lial cells of 50 individuals withagenesia in second premolars orthird molars and 50 controlind ivid ua ls. The BMP-4 genepromoting regionwas amplified bythe PCR technique. The productsofpurified PCRwere submitted toautomatic sequencing and did notreveal any alterations in the regionofthe. studied genet These resultsindicate that other genes orregions ofBMP-4must be involvedin the etiology of hypodontia inhumans." @default.
- W1556441133 created "2016-06-24" @default.
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- W1556441133 date "2003-05-21" @default.
- W1556441133 modified "2023-09-24" @default.
- W1556441133 title "Investigação de polimorfismos na região promotora do gene BMP-4 em individuos com agenesia dental" @default.
- W1556441133 doi "https://doi.org/10.5335/rfo.v9i1.1656" @default.
- W1556441133 hasPublicationYear "2003" @default.
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