Matches in SemOpenAlex for { <https://semopenalex.org/work/W1556501207> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W1556501207 abstract "OBJECTIVE: To evaluate the pharmacokinetics of cefetamet pivoxil and possible interaction with N-acetylcysteine and cisapride in healthy volunteers. METHODS: In a double-blind, randomized three-way crossover study with 12 healthy male volunteers, serum and urine concentrations of cefetamet were determined over 12 h by a validated bioassay method after oral administration of 0.5 g cefetamet pivoxil and, randomly, placebo, 5x20 mg cisapride, or 0.6 g N-acetylcysteine. RESULTS: The study medications were well tolerated, although there were 10 cases of altered bowel movements, two cases of mild, transient headache and one case of increased serum transferase levels (AST and ALT). The mean peak serum level of cefetamet pivoxil in the placebo group was 4.86plus minus1.35 mg/L. The urine recovery/24 h in the placebo group was 41.9plus minus3.8% of the oral dose. The elimination half-life was 3.56plus minus0.92 h. N-Acetylcysteine had no effect on the pharmacokinetics of cefetamet pivoxil. With concomitant administration of cisapride there was an accelerated absorption of cefetamet pivoxil and a slightly increased Cmax of cefetamet. The Cmax values differed significantly (p<0.05) only between the cisapride group (5.76plus minus1.50 mg/L) and the N-acetylcysteine group (4.53plus minus1.18 mg/L). CONCLUSION: None of the small pharmacokinetic differences between the three groups is expected to have any relevance in the treatment of infectious diseases with cefetamet pivoxil." @default.
- W1556501207 created "2016-06-24" @default.
- W1556501207 creator A5022041021 @default.
- W1556501207 creator A5037496599 @default.
- W1556501207 creator A5038492645 @default.
- W1556501207 creator A5047335873 @default.
- W1556501207 creator A5047592238 @default.
- W1556501207 creator A5066558918 @default.
- W1556501207 creator A5075891046 @default.
- W1556501207 date "1997-04-01" @default.
- W1556501207 modified "2023-09-27" @default.
- W1556501207 title "Pharmacokinetics of cefetamet pivoxil and interaction with cisapride and N-acetylcysteine" @default.
- W1556501207 cites W1894561466 @default.
- W1556501207 cites W1985804767 @default.
- W1556501207 cites W1986185948 @default.
- W1556501207 cites W1994073078 @default.
- W1556501207 cites W2014431091 @default.
- W1556501207 cites W2022989126 @default.
- W1556501207 cites W2029666341 @default.
- W1556501207 cites W2030445992 @default.
- W1556501207 cites W2039763489 @default.
- W1556501207 cites W2070771058 @default.
- W1556501207 cites W2091306315 @default.
- W1556501207 cites W2104894051 @default.
- W1556501207 cites W2168175751 @default.
- W1556501207 cites W2326110241 @default.
- W1556501207 cites W2610793288 @default.
- W1556501207 doi "https://doi.org/10.1111/j.1469-0691.1997.tb00593.x" @default.
- W1556501207 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11864100" @default.
- W1556501207 hasPublicationYear "1997" @default.
- W1556501207 type Work @default.
- W1556501207 sameAs 1556501207 @default.
- W1556501207 citedByCount "0" @default.
- W1556501207 crossrefType "journal-article" @default.
- W1556501207 hasAuthorship W1556501207A5022041021 @default.
- W1556501207 hasAuthorship W1556501207A5037496599 @default.
- W1556501207 hasAuthorship W1556501207A5038492645 @default.
- W1556501207 hasAuthorship W1556501207A5047335873 @default.
- W1556501207 hasAuthorship W1556501207A5047592238 @default.
- W1556501207 hasAuthorship W1556501207A5066558918 @default.
- W1556501207 hasAuthorship W1556501207A5075891046 @default.
- W1556501207 hasBestOaLocation W15565012071 @default.
- W1556501207 hasConcept C112705442 @default.
- W1556501207 hasConcept C126322002 @default.
- W1556501207 hasConcept C142724271 @default.
- W1556501207 hasConcept C185592680 @default.
- W1556501207 hasConcept C204787440 @default.
- W1556501207 hasConcept C27081682 @default.
- W1556501207 hasConcept C2776119469 @default.
- W1556501207 hasConcept C2777056448 @default.
- W1556501207 hasConcept C2777847592 @default.
- W1556501207 hasConcept C2778004101 @default.
- W1556501207 hasConcept C2780026642 @default.
- W1556501207 hasConcept C55493867 @default.
- W1556501207 hasConcept C71924100 @default.
- W1556501207 hasConcept C87813604 @default.
- W1556501207 hasConcept C98274493 @default.
- W1556501207 hasConceptScore W1556501207C112705442 @default.
- W1556501207 hasConceptScore W1556501207C126322002 @default.
- W1556501207 hasConceptScore W1556501207C142724271 @default.
- W1556501207 hasConceptScore W1556501207C185592680 @default.
- W1556501207 hasConceptScore W1556501207C204787440 @default.
- W1556501207 hasConceptScore W1556501207C27081682 @default.
- W1556501207 hasConceptScore W1556501207C2776119469 @default.
- W1556501207 hasConceptScore W1556501207C2777056448 @default.
- W1556501207 hasConceptScore W1556501207C2777847592 @default.
- W1556501207 hasConceptScore W1556501207C2778004101 @default.
- W1556501207 hasConceptScore W1556501207C2780026642 @default.
- W1556501207 hasConceptScore W1556501207C55493867 @default.
- W1556501207 hasConceptScore W1556501207C71924100 @default.
- W1556501207 hasConceptScore W1556501207C87813604 @default.
- W1556501207 hasConceptScore W1556501207C98274493 @default.
- W1556501207 hasLocation W15565012071 @default.
- W1556501207 hasLocation W15565012072 @default.
- W1556501207 hasOpenAccess W1556501207 @default.
- W1556501207 hasPrimaryLocation W15565012071 @default.
- W1556501207 hasRelatedWork W1925245215 @default.
- W1556501207 hasRelatedWork W1991741431 @default.
- W1556501207 hasRelatedWork W1992918939 @default.
- W1556501207 hasRelatedWork W1994073078 @default.
- W1556501207 hasRelatedWork W1999818440 @default.
- W1556501207 hasRelatedWork W2006024908 @default.
- W1556501207 hasRelatedWork W2007196783 @default.
- W1556501207 hasRelatedWork W2033704895 @default.
- W1556501207 hasRelatedWork W2059060527 @default.
- W1556501207 hasRelatedWork W2068493248 @default.
- W1556501207 hasRelatedWork W2091119386 @default.
- W1556501207 hasRelatedWork W2115747428 @default.
- W1556501207 hasRelatedWork W2122269506 @default.
- W1556501207 hasRelatedWork W2126443873 @default.
- W1556501207 hasRelatedWork W2129180868 @default.
- W1556501207 hasRelatedWork W2152361760 @default.
- W1556501207 hasRelatedWork W2513394932 @default.
- W1556501207 hasRelatedWork W2955082406 @default.
- W1556501207 hasRelatedWork W3140527952 @default.
- W1556501207 hasRelatedWork W2405788664 @default.
- W1556501207 isParatext "false" @default.
- W1556501207 isRetracted "false" @default.
- W1556501207 magId "1556501207" @default.
- W1556501207 workType "article" @default.