FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1556555719> ?p ?o ?g. }

• W1556555719 endingPage "e204" @default.
• W1556555719 startingPage "e194" @default.
• W1556555719 abstract "Background The purinergic component of enteric inhibitory neurotransmission is important for normal motility in the gastrointestinal (GI) tract. Controversies exist about the purine(s) responsible for inhibitory responses in GI muscles: ATP has been assumed to be the purinergic neurotransmitter released from enteric inhibitory motor neurons; however, recent studies demonstrate that β-nicotinamide adenine dinucleotide (β-NAD+) and ADP-ribose mimic the inhibitory neurotransmitter better than ATP in primate and murine colons. The study was designed to clarify the sources of purines in colons of Cynomolgus monkeys and C57BL/6 mice. Methods High-performance liquid chromatography with fluorescence detection was used to analyze purines released by stimulation of nicotinic acetylcholine receptors (nAChR) and serotonergic 5-HT3 receptors (5-HT3R), known to be present on cell bodies and dendrites of neurons within the myenteric plexus. Key Results Nicotinic acetylcholine receptor or 5-HT3R agonists increased overflow of ATP and β-NAD+ from tunica muscularis of monkey and murine colon. The agonists did not release purines from circular muscles of monkey colon lacking myenteric ganglia. Agonist-evoked overflow of β-NAD+, but not ATP, was inhibited by tetrodotoxin (0.5 μmol L−1) or ω-conotoxin GVIA (50 nmol L−1), suggesting that β-NAD+ release requires nerve action potentials and junctional mechanisms known to be critical for neurotransmission. ATP was likely released from nerve cell bodies in myenteric ganglia and not from nerve terminals of motor neurons. Conclusions & Inferences These results support the conclusion that ATP is not a motor neurotransmitter in the colon and are consistent with the hypothesis that β-NAD+, or its metabolites, serve as the purinergic inhibitory neurotransmitter." @default.
• W1556555719 created "2016-06-24" @default.
• W1556555719 creator A5028080442 @default.
• W1556555719 creator A5082457372 @default.
• W1556555719 creator A5083801595 @default.
• W1556555719 date "2013-01-02" @default.
• W1556555719 modified "2023-10-18" @default.
• W1556555719 title "Differential release of β-NAD⁺and ATP upon activation of enteric motor neurons in primate and murine colons" @default.
• W1556555719 cites W1530088271 @default.
• W1556555719 cites W1594018550 @default.
• W1556555719 cites W1965121027 @default.
• W1556555719 cites W1966806312 @default.
• W1556555719 cites W1968856852 @default.
• W1556555719 cites W1969545527 @default.
• W1556555719 cites W1970884325 @default.
• W1556555719 cites W1972395049 @default.
• W1556555719 cites W1972988032 @default.
• W1556555719 cites W1974270902 @default.
• W1556555719 cites W1999155032 @default.
• W1556555719 cites W2004862250 @default.
• W1556555719 cites W2005810799 @default.
• W1556555719 cites W2006710293 @default.
• W1556555719 cites W2011791847 @default.
• W1556555719 cites W2014858313 @default.
• W1556555719 cites W2020372793 @default.
• W1556555719 cites W2033823376 @default.
• W1556555719 cites W2039298574 @default.
• W1556555719 cites W2042439021 @default.
• W1556555719 cites W2042865941 @default.
• W1556555719 cites W2045374278 @default.
• W1556555719 cites W2045576152 @default.
• W1556555719 cites W2058888175 @default.
• W1556555719 cites W2071037168 @default.
• W1556555719 cites W2075124455 @default.
• W1556555719 cites W2075848594 @default.
• W1556555719 cites W2077354720 @default.
• W1556555719 cites W2080731085 @default.
• W1556555719 cites W2081391428 @default.
• W1556555719 cites W2091277867 @default.
• W1556555719 cites W2095139743 @default.
• W1556555719 cites W2096698561 @default.
• W1556555719 cites W2098267014 @default.
• W1556555719 cites W2106952728 @default.
• W1556555719 cites W2116833507 @default.
• W1556555719 cites W2127279432 @default.
• W1556555719 cites W2132493347 @default.
• W1556555719 cites W2133583538 @default.
• W1556555719 cites W2147928251 @default.
• W1556555719 cites W2159271666 @default.
• W1556555719 cites W3166732914 @default.
• W1556555719 cites W4233594215 @default.
• W1556555719 doi "https://doi.org/10.1111/nmo.12069" @default.
• W1556555719 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3578016" @default.
• W1556555719 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23279315" @default.
• W1556555719 hasPublicationYear "2013" @default.
• W1556555719 type Work @default.
• W1556555719 sameAs 1556555719 @default.
• W1556555719 citedByCount "27" @default.
• W1556555719 countsByYear W15565557192013 @default.
• W1556555719 countsByYear W15565557192014 @default.
• W1556555719 countsByYear W15565557192015 @default.
• W1556555719 countsByYear W15565557192016 @default.
• W1556555719 countsByYear W15565557192017 @default.
• W1556555719 countsByYear W15565557192019 @default.
• W1556555719 countsByYear W15565557192020 @default.
• W1556555719 countsByYear W15565557192021 @default.
• W1556555719 countsByYear W15565557192022 @default.
• W1556555719 crossrefType "journal-article" @default.
• W1556555719 hasAuthorship W1556555719A5028080442 @default.
• W1556555719 hasAuthorship W1556555719A5082457372 @default.
• W1556555719 hasAuthorship W1556555719A5083801595 @default.
• W1556555719 hasBestOaLocation W15565557192 @default.
• W1556555719 hasConcept C126322002 @default.
• W1556555719 hasConcept C134018914 @default.
• W1556555719 hasConcept C170493617 @default.
• W1556555719 hasConcept C17077164 @default.
• W1556555719 hasConcept C172590197 @default.
• W1556555719 hasConcept C181199279 @default.
• W1556555719 hasConcept C188987157 @default.
• W1556555719 hasConcept C200170125 @default.
• W1556555719 hasConcept C203014093 @default.
• W1556555719 hasConcept C204232928 @default.
• W1556555719 hasConcept C2775910092 @default.
• W1556555719 hasConcept C2776219046 @default.
• W1556555719 hasConcept C2776741303 @default.
• W1556555719 hasConcept C2776901170 @default.
• W1556555719 hasConcept C2776907353 @default.
• W1556555719 hasConcept C2777439022 @default.
• W1556555719 hasConcept C2778938600 @default.
• W1556555719 hasConcept C3020341438 @default.
• W1556555719 hasConcept C55493867 @default.
• W1556555719 hasConcept C57306754 @default.
• W1556555719 hasConcept C67907053 @default.
• W1556555719 hasConcept C71924100 @default.
• W1556555719 hasConcept C75520062 @default.
• W1556555719 hasConcept C86803240 @default.
• W1556555719 hasConceptScore W1556555719C126322002 @default.
• W1556555719 hasConceptScore W1556555719C134018914 @default.

• next