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• W1556567074 abstract "During the last decade a growing interest in vitamin D-related problems can be observed and a few thousands of scientific publications are dedicated to this task every year. The alarming statistical data regarding propagation of vitamin D deficiency in all continents and our developing knowledge about novel, non-calcemic actions of vitamin D seem to be two main causes of this phenomenon. Indeed, recent epidemiological studies suggest that worldwide prevalence of inadequate vitamin D status is higher than expected, however it may result from different factors, including geographical location and cultural background. Since vitamin D skin synthesis, which takes place under the influence of the sun’s ultraviolet B (UVB) radiation, covers as much as 90% of total body needs, inadequate radiation or insufficient cutaneous absorption of UVB are regarded as major causes of vitamin D deficiency. Air pollution is a chief factor determining the extent of solar UVB that reaches earth surface and several epidemiological data, which represents different populations living in different geographic latitudes, indicate that atmospheric pollution (especially high tropospheric ozone content) may play a significant independent role in the development of vitamin D deficiency. As a result prevalence of D hypovitaminosis among urban residents can be more than twice higher than that of rural inhabitants. The problem of vitamin D insufficiency has been underestimated for many years and it has been predominantly associated only with bone diseases. Discovery of vitamin D receptor and its identification in a wide number of tissues other than bones led to the designation of novel, so-called “non-calcemic” (e.g. antiproliferative and immunomodulatory), actions of cholecalciferol. Subsequently, there is a growing number of diseases and conditions, development and/or progression of which can be associated with inadequate vitamin D status, including different types of cancers, autoimmune disorders as well as cardiovascular events. Interestingly, prevalence of many of these diseases also positively correlates with the intensity of air pollution. Therefore one can conclude that with the increasing atmospheric pollution grows a number of people in the world who are vitamin D deficient or insufficient and indirectly exposed to several poor health outcomes. This chapter gives an overview of the literature on this topic and assesses the available data about the association between air pollution, vitamin D status and prevalence of so-called civilization-related diseases. A general information regarding vitamin D metabolism is" @default.
• W1556567074 created "2016-06-24" @default.
• W1556567074 creator A5037147606 @default.
• W1556567074 date "2011-09-26" @default.
• W1556567074 modified "2023-10-18" @default.
• W1556567074 title "Impact of Air Pollution on Vitamin D Status and Related Health Consequences" @default.
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