FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1556574075> ?p ?o ?g. }

• W1556574075 endingPage "3032" @default.
• W1556574075 startingPage "3025" @default.
• W1556574075 abstract "Signals elicited by TLRs following the detection of microbes are integrated and diversified by a group of four cytoplasmic adaptor molecules featuring an evolutionarily conserved Toll/IL-1R signaling domain. Single nucleotide polymorphisms (SNPs) in TLRs and their adaptor molecules have been shown to influence susceptibility to a range of infectious and other diseases. The adaptor MyD88 adaptor-like (Mal)/Toll/IL-1R-containing adaptor protein is involved in TLR2 and 4 signal transduction by recruiting another adaptor molecule, MyD88, to the plasma membrane. In this study, we used naturally occurring variants of Mal as tools to study the molecular biology of Mal in more detail in cellular model systems and to thereby identify functionally interesting variants whose corresponding nonsynonymous SNPs might be of further epidemiological interest. Of seven reported variants for Mal, we found Mal D96N associated with reduced NF-kappaB signaling and cytokine production after overexpression in HEK293 and Huh-7 cells. The D96N mutation prevented Mal from recruiting its signaling partner MyD88 to the plasma membrane and altered posttranslational modification of Mal. These findings led us to investigate the frequency of heterozygosity for the corresponding SNP rs8177400 in a Caucasian case-control study on the etiology of lymphoma, a disease in which TLRs have been implicated. Although rs8177400 did not modify lymphoma risk in general, its frequency of heterozygosity was accurately determined to 0.97%. Our data add rs8177400 (D96N) to the list of functionally important variants of Mal and warrant further research into its immunological, epidemiological, and diagnostic relevance." @default.
• W1556574075 created "2016-06-24" @default.
• W1556574075 creator A5019552808 @default.
• W1556574075 creator A5027231761 @default.
• W1556574075 creator A5033744801 @default.
• W1556574075 creator A5037138357 @default.
• W1556574075 creator A5043483596 @default.
• W1556574075 creator A5053919467 @default.
• W1556574075 creator A5065421365 @default.
• W1556574075 creator A5073565228 @default.
• W1556574075 creator A5087618277 @default.
• W1556574075 date "2010-03-15" @default.
• W1556574075 modified "2023-10-04" @default.
• W1556574075 title "MyD88 Adaptor-Like D96N Is a Naturally Occurring Loss-of-Function Variant of <i>TIRAP</i>" @default.
• W1556574075 cites W1519843522 @default.
• W1556574075 cites W1925157258 @default.
• W1556574075 cites W1966772446 @default.
• W1556574075 cites W1966829374 @default.
• W1556574075 cites W1972642574 @default.
• W1556574075 cites W1994793165 @default.
• W1556574075 cites W1998055077 @default.
• W1556574075 cites W2004312418 @default.
• W1556574075 cites W2016928596 @default.
• W1556574075 cites W2035630729 @default.
• W1556574075 cites W2043823247 @default.
• W1556574075 cites W2044261235 @default.
• W1556574075 cites W2044954245 @default.
• W1556574075 cites W2058401000 @default.
• W1556574075 cites W2079955793 @default.
• W1556574075 cites W2080384080 @default.
• W1556574075 cites W2090640877 @default.
• W1556574075 cites W2098819090 @default.
• W1556574075 cites W2110061191 @default.
• W1556574075 cites W2115135651 @default.
• W1556574075 cites W2127533700 @default.
• W1556574075 cites W2129546321 @default.
• W1556574075 cites W2141040025 @default.
• W1556574075 cites W2144136875 @default.
• W1556574075 cites W2147038697 @default.
• W1556574075 cites W2163312887 @default.
• W1556574075 cites W2171260427 @default.
• W1556574075 cites W4241949506 @default.
• W1556574075 doi "https://doi.org/10.4049/jimmunol.0901156" @default.
• W1556574075 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20164415" @default.
• W1556574075 hasPublicationYear "2010" @default.
• W1556574075 type Work @default.
• W1556574075 sameAs 1556574075 @default.
• W1556574075 citedByCount "31" @default.
• W1556574075 countsByYear W15565740752012 @default.
• W1556574075 countsByYear W15565740752013 @default.
• W1556574075 countsByYear W15565740752014 @default.
• W1556574075 countsByYear W15565740752015 @default.
• W1556574075 countsByYear W15565740752016 @default.
• W1556574075 countsByYear W15565740752017 @default.
• W1556574075 countsByYear W15565740752019 @default.
• W1556574075 countsByYear W15565740752020 @default.
• W1556574075 countsByYear W15565740752021 @default.
• W1556574075 countsByYear W15565740752022 @default.
• W1556574075 countsByYear W15565740752023 @default.
• W1556574075 crossrefType "journal-article" @default.
• W1556574075 hasAuthorship W1556574075A5019552808 @default.
• W1556574075 hasAuthorship W1556574075A5027231761 @default.
• W1556574075 hasAuthorship W1556574075A5033744801 @default.
• W1556574075 hasAuthorship W1556574075A5037138357 @default.
• W1556574075 hasAuthorship W1556574075A5043483596 @default.
• W1556574075 hasAuthorship W1556574075A5053919467 @default.
• W1556574075 hasAuthorship W1556574075A5065421365 @default.
• W1556574075 hasAuthorship W1556574075A5073565228 @default.
• W1556574075 hasAuthorship W1556574075A5087618277 @default.
• W1556574075 hasBestOaLocation W15565740751 @default.
• W1556574075 hasConcept C104317684 @default.
• W1556574075 hasConcept C141231307 @default.
• W1556574075 hasConcept C149904235 @default.
• W1556574075 hasConcept C183786373 @default.
• W1556574075 hasConcept C54355233 @default.
• W1556574075 hasConcept C62478195 @default.
• W1556574075 hasConcept C86803240 @default.
• W1556574075 hasConcept C95444343 @default.
• W1556574075 hasConceptScore W1556574075C104317684 @default.
• W1556574075 hasConceptScore W1556574075C141231307 @default.
• W1556574075 hasConceptScore W1556574075C149904235 @default.
• W1556574075 hasConceptScore W1556574075C183786373 @default.
• W1556574075 hasConceptScore W1556574075C54355233 @default.
• W1556574075 hasConceptScore W1556574075C62478195 @default.
• W1556574075 hasConceptScore W1556574075C86803240 @default.
• W1556574075 hasConceptScore W1556574075C95444343 @default.
• W1556574075 hasIssue "6" @default.
• W1556574075 hasLocation W15565740751 @default.
• W1556574075 hasLocation W15565740752 @default.
• W1556574075 hasOpenAccess W1556574075 @default.
• W1556574075 hasPrimaryLocation W15565740751 @default.
• W1556574075 hasRelatedWork W1975510716 @default.
• W1556574075 hasRelatedWork W1978760124 @default.
• W1556574075 hasRelatedWork W1994052653 @default.
• W1556574075 hasRelatedWork W2002128513 @default.
• W1556574075 hasRelatedWork W2100964397 @default.
• W1556574075 hasRelatedWork W2126290201 @default.
• W1556574075 hasRelatedWork W2144354735 @default.

• next