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• W1556593070 abstract "The brain uses lactate produced by glycolysis as an energy source. How lactate originated from the blood stream is used to fuel brain metabolism is not clear. The current study measures brain metabolic fluxes and estimates the amount of pyruvate that becomes labeled in glial and neuronal compartments upon infusion of [3‐ 13 C]lactate. For that, labeling incorporation into carbons of glutamate and glutamine was measured by 13 C magnetic resonance spectroscopy at 14.1 T and analyzed with a two‐compartment model of brain metabolism to estimate rates of mitochondrial oxidation, glial pyruvate carboxylation, and the glutamate–glutamine cycle as well as pyruvate fractional enrichments. Extracerebral lactate at supraphysiological levels contributes at least two‐fold more to replenish the neuronal than the glial pyruvate pools. The rates of mitochondrial oxidation in neurons and glia, pyruvate carboxylase, and glutamate–glutamine cycles were similar to those estimated by administration of 13 C‐enriched glucose, the main fuel of brain energy metabolism. These results are in agreement with primary utilization of exogenous lactate in neurons rather than astrocytes. © 2014 Wiley Periodicals, Inc." @default.
• W1556593070 created "2016-06-24" @default.
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• W1556593070 date "2014-12-17" @default.
• W1556593070 modified "2023-10-16" @default.
• W1556593070 title "Brain energy metabolism measured by¹³C magnetic resonance spectroscopy in vivo upon infusion of [3-¹³C]lactate" @default.
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• W1556593070 doi "https://doi.org/10.1002/jnr.23531" @default.
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