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• W1556615320 abstract "Tuberculosis (TB) remains a serious human health problem that affects millions of people in the world. Understanding the biology of Mycobacterium tuberculosis (Mtb) is essential for tackling this devastating disease. Mtb possesses a very complex cell envelope containing a variety of lipid components that participate in the establishment of the infection. We have previously demonstrated that di-O-acylated trehalose (DAT), a non-covalently linked cell wall glycolipid, inhibits the proliferation of T lymphocytes and the production of cytokines.In this work we show that DAT and the closely related tri-O-acylated trehalose (TAT) inhibits nitric oxide (NO) production and the inducible nitric oxide synthase (iNOS) expression in macrophages (MØ).These findings show that DAT and TAT are cell-wall located virulence factors that downregulate an important effector of the immune response against mycobacteria." @default.
• W1556615320 created "2016-06-24" @default.
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• W1556615320 date "2015-06-23" @default.
• W1556615320 modified "2023-10-09" @default.
• W1556615320 title "Mycobacterial glycolipids di-O-acylated trehalose and tri-O-acylated trehalose downregulate inducible nitric oxide synthase and nitric oxide production in macrophages" @default.
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• W1556615320 doi "https://doi.org/10.1186/s12865-015-0102-3" @default.
• W1556615320 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4477496" @default.
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