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- W1556659917 abstract "There is emerging evidence that the adenosinergic system might be involved in drug addiction and alcohol dependence. We have already demonstrated the involvement of A2A receptors (A2AR) in ethanol-related behaviours in mice. Here, we investigated whether the A2AR agonist CGS 21680 can reduce ethanol operant self-administration in both non-dependent and ethanol-dependent Wistar rats. To rule out a potential involvement of the A1R in the effects of CGS 21680, we also tested its effectiveness to reduce ethanol operant self-administration in both heterozygous and homozygous A1R knockout mice. Our results demonstrated that CGS 21680 (0.065, 0.095 and 0.125 mg/kg, i.p.) had a bimodal effect on 10% ethanol operant self-administration in non-dependent rats. The intermediate dose was also effective in reducing 2% sucrose self-administration. Interestingly, the intermediate dose reduced 10% ethanol self-administration in dependent animals more effectively (75% decrease) when compared with non-dependent animals (57% decrease). These results suggest that the A2AR are involved in CGS 21680 effects since the reduction of ethanol self-administration was not dependent upon the presence of A1R in mice. In conclusion, our findings demonstrated the effectiveness of the A2AR agonist CGS 21680 in a preclinical model of alcohol addiction and suggested that the adenosinergic pathway is a promising target to treat alcohol addiction." @default.
- W1556659917 created "2016-06-24" @default.
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- W1556659917 date "2013-01-10" @default.
- W1556659917 modified "2023-10-06" @default.
- W1556659917 title "The adenosine A2A receptor agonist CGS 21680 decreases ethanol self-administration in both non-dependent and dependent animals" @default.
- W1556659917 cites W1490848194 @default.
- W1556659917 cites W1529221656 @default.
- W1556659917 cites W1562285676 @default.
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- W1556659917 cites W1654795077 @default.
- W1556659917 cites W1813175747 @default.
- W1556659917 cites W1886452735 @default.
- W1556659917 cites W1925945475 @default.
- W1556659917 cites W1966980993 @default.
- W1556659917 cites W1977233750 @default.
- W1556659917 cites W1983934270 @default.
- W1556659917 cites W1989467245 @default.
- W1556659917 cites W1990980958 @default.
- W1556659917 cites W1995941325 @default.
- W1556659917 cites W1997953094 @default.
- W1556659917 cites W2006331600 @default.
- W1556659917 cites W2007287690 @default.
- W1556659917 cites W2011079069 @default.
- W1556659917 cites W2012783828 @default.
- W1556659917 cites W2015492904 @default.
- W1556659917 cites W2017228134 @default.
- W1556659917 cites W2019202457 @default.
- W1556659917 cites W2022844399 @default.
- W1556659917 cites W2023622729 @default.
- W1556659917 cites W2026598376 @default.
- W1556659917 cites W2027770318 @default.
- W1556659917 cites W2033118995 @default.
- W1556659917 cites W2033564079 @default.
- W1556659917 cites W2041878895 @default.
- W1556659917 cites W2044801980 @default.
- W1556659917 cites W2048579467 @default.
- W1556659917 cites W2053650795 @default.
- W1556659917 cites W2056310693 @default.
- W1556659917 cites W2057411906 @default.
- W1556659917 cites W2058704897 @default.
- W1556659917 cites W2060985317 @default.
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- W1556659917 cites W2062740729 @default.
- W1556659917 cites W2065939798 @default.
- W1556659917 cites W2066244040 @default.
- W1556659917 cites W2067438050 @default.
- W1556659917 cites W2067467266 @default.
- W1556659917 cites W2068153172 @default.
- W1556659917 cites W2069461127 @default.
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- W1556659917 cites W2135732482 @default.
- W1556659917 cites W2135903564 @default.
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- W1556659917 cites W2159427608 @default.
- W1556659917 cites W2160526441 @default.
- W1556659917 cites W2160911543 @default.
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- W1556659917 cites W2214185525 @default.
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- W1556659917 doi "https://doi.org/10.1111/adb.12032" @default.
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