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• W155673874 abstract "Delayed Enhancement Magnetic Resonance Imaging (DE-MRI) is a widely used imaging tool in the assessment of ischemic pathologies, crucial in distinguishing between infarcted and healthy myocardium [1]. Usually, T1 weighted images are acquired using an Electrocardiogram (ECG) triggered Inversion Recovery (IR) sequence after contrast agent injection which allows to increase signal contrast between the two tissues. Since DE-MRI is cardiac triggered, heart rate (HR) irregularities directly affect signal behaviour. When HR varies, the time for the longitudinal magnetization (Mz) to recover is different for each cycle which leads to a different amount of magnetization available for acquisition. This irregular signal intensity can cause strong image artefacts. Therefore, the purpose of this study was to develop a novel acquisition approach to compensate for HR variations using a multi-tissue model. Optimal Inversion Time (TI) values for each cycle were obtained by minimizing Mz variations of the healthy myocardium (SSEmyocardium) and blood (SSEblood): SSEtotal = W ∗ SSEmyocardium + (1−W )∗SSEblood. The weighting (W) allows to correct more strongly for artefacts from blood (W 0.5) to achieve the best image quality possible. Simulations were performed to study signal behaviour and test the proposed multitissue correction approach. In addition, the method was also implemented on a 3T scanner and phantom experiments verified the simulated results. The proposed multi-tissue method was successful when compensating for artefacts. For 30% HR variation scenario, it reduced image artefacts by approximately 70 % compared with a non-corrected image which is 20 and 45 % more than the single-tissue approach, only blood or healthy myocardium respectively. In conclusion, not only the proposed multi-tissue method can be successfully used to reduce image artefacts, but also leads to a better image quality than some previously" @default.
• W155673874 created "2016-06-24" @default.
• W155673874 creator A5040618477 @default.
• W155673874 date "2013-01-01" @default.
• W155673874 modified "2023-09-27" @default.
• W155673874 title "Delayed Enhancement cardiac MRI: reduction of image artefacts in patients with irregular heart rate" @default.
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• W155673874 hasPublicationYear "2013" @default.
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