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- W15567923 abstract "Tubular segments distal (downstream) and proximal (upstream) to the macula densa are closely associated with the afferent and efferent arterioles, respectively. The epithelial cells in the perimeter of the macula densa demonstrate spontaneous oscillations in intracellular calcium concentration ([Ca2+]i). We hypothesized that intracellular Ca2+ signaling in the tubular segment proximal to the macula densa might be associated with intracellular Ca2+ changes in the adjacent efferent arteriole. We utilized isolated perfused cortical thick ascending limb (cTAL) with attached glomerulus-efferent arteriole and assessed [Ca2+]i in the tubular and vascular elements with widefield fluorescence microscopy using fura-2 or multiphoton excitation fluorescence microscopy and 4-dimensional volume-rendering. Here we report that the vascular smooth muscle cells of the efferent arteriole and the epithelial cells of the adjacent cTAL demonstrate synchronous oscillations or spikes in [Ca2+]i. Interestingly, the initiation of an oscillation in [Ca2+]i in the efferent arteriole required [Ca2+]i in the tubular epithelium to reach an apparent threshold. Dissection of the efferent arteriole away from the cTAL reduced the amplitude of oscillations in the efferent arteriole. Also, luminal administration of furosemide, an inhibitor of the Na+:2Cl−:K+ cotransporter, blocked the amplitude of oscillations in the epithelial cells of the cTAL by 53 %, hydrochlorothiazide from the lumen had no effect. These findings suggest that the tubular segment downstream from the macula densa possess oscillations in [Ca2+]i which may play a role in signaling to the efferent arteriole." @default.
- W15567923 created "2016-06-24" @default.
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- W15567923 date "2006-03-01" @default.
- W15567923 modified "2023-10-16" @default.
- W15567923 title "Oscillatory juxtaglomerular tubular cells – a possible new tubule‐to‐arteriole signaling pathway" @default.
- W15567923 doi "https://doi.org/10.1096/fasebj.20.5.lb39" @default.
- W15567923 hasPublicationYear "2006" @default.
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