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- W1556821662 abstract "To determine if a hypermethylation defect occurs in human breast cancer, the expression profile and promoter methylation status of 64 methylation-sensitive genes was evaluated among 12 human breast cancer cell lines. Unsupervised cluster analysis of gene expression patterns revealed two groups of cell lines that possess distinct methylation signatures: (i) hypermethylator cell lines, and (ii) low-frequency methylator cell lines. The hypermethylator cell lines are characterized by high rates of concurrent methylation of six genes (CDH1, CEACAM6, CST6, ESR1, LCN2, and SCNN1A), whereas the low-frequency methylator cell lines do not methylate these genes. Hypermethylator cell lines coordinately overexpress (R=0.71) total DNMT activity (∼2-6-fold higher) and DNMT3b protein levels (∼2-4-fold higher) compared to normal breast MCF12A cells. In contrast, most low-frequency methylator cell lines possess DNMT activity and protein levels that are indistinguishable from those of MCF12A cells. These observations combine to strongly suggest that: (a) a subset of human breast cancer cell lines express a hypermethylator phenotype related to overexpression of DNMT activity, and (b) overexpression of DNMT3b protein significantly contributes to the elevated DNMT activity observed in breast cancer cell lines that express this hypermethylator phenotype. Support: NIH CA78343." @default.
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- W1556821662 date "2008-03-01" @default.
- W1556821662 modified "2023-09-27" @default.
- W1556821662 title "DNMT3b overexpression contributes to a hypermethylator phenotype in human breast cancer cell lines" @default.
- W1556821662 doi "https://doi.org/10.1096/fasebj.22.1_supplement.898.17" @default.
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