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- W1556885003 abstract "2-Amino-3-methylimidazo[4,5-f]quinoline (IQ) is a potent bacterial mutagen formed during cooking of beef. IQ was administered intravenously to Sprague-Dawley rats at concentrations ranging from 7.5-50 mg/kg body weight. Urine was collected and analyzed for mutagenicity. Urinary mutagens were found which required activation by S9 mix, and reverted Ames test strains TA98 and TA100, but not TA1535 or TA1537. The amount of urinary mutagen(s) were related to IQ dose administered and were excreted within 48 h. Additional mutagenic activity was not released after incubation with beta-glucuronidase or aryl sulfatase. Analysis of urinary mutagens by HPLC indicates that the majority of mutagenic activity is due to unchanged IQ, but a small peak of mutagenic activity may correspond to N-acetyl or 3-N-demethylated metabolite. Since only 1% of the administered mutagenic activity is recovered in the urine, IQ may be readily detoxified in vivo." @default.
- W1556885003 created "2016-06-24" @default.
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- W1556885003 date "1985-04-01" @default.
- W1556885003 modified "2023-09-25" @default.
- W1556885003 title "Fate of the food mutagen 2-amino-3-methylimidazo[4,5-ƒ]quinoline (IQ) in Sprague-Dawley rats" @default.
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- W1556885003 doi "https://doi.org/10.1016/0165-1218(85)90010-2" @default.
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