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- W1556897021 abstract "4598 Background: Barrett’s metaplasia is an acquired condition caused by protracted gastroesophageal reflux and involves replacement of normal squamous with the columnar, intestinal type epithelium. Patients diagnosed with Barrett’s metaplasia have a 30- to 40-fold increased risk of developing adenocarcinoma compared with the general population. MTHFR plays a central role in folate metabolism that affects DNA methylation and synthesis. Germ-line mutations at nucleotides 677 (C–>T) and 1298 (A–>C) in the MTHFR gene cause diminished enzyme activity, and previous studies found that the allele frequency of MTHFR 677T was significantly higher among patients with esophageal squamous cell carcinoma (ESCC) than among controls (63% versus 41%, P" @default.
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- W1556897021 date "2006-04-15" @default.
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- W1556897021 title "Role of MTHFR gene polymorphisms in malignant transformation in Barrett’s metaplasia" @default.
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