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- W1556931679 abstract "Unpredictable responses in SN counts were observed in infants following the transfusion of irradiated neutrophils(11.6± 3.3cc/kg) during therapy for neonatal sepsis. Sixteen infants (BW.1880±770g, GA.33±44 wks) were transfused at a mean age of 65.5±43.8 hours. SN count pre(58.4±44.3 hours) and post(67.3±40.1 hours) transfusion was 1350±1070/cu.mm.,and 3177±2493/cu.mm., respectively (p<0.02). Three pre SN counts were used to calculate a rate of SN change. Using these values to predict expected counts without transfusion, four types of responses were noted among three post counts in survivors; full response (N=6),early response(N=3), late response(N=1), and no response (N=4). Blood cultures were positive in 6 (BW.2460±570g)and negative in 10(BW.1550±680g). Septic infants were transfused earlier (36.3±21.7 vs.83.7±45.0 hours), and responded better (pre: 1456 ± 1062/cu.mm. to post: 4857±2935/cu.mm.)than the culture negative group(pre: 1285±1127/cu.mm. to post 2058±1401/cu.mm.)These differences were significant at p<0.05.The only post-transfusion count drop occurred in 1 of 2 deaths in the septic group: from 650/cu.mm. to 640/cu.mm. The response of the SN count to neutrophil transfusion was erratic and unpredictable in this group of infants.This response did not correlate with BW, volume, or age at transfusion.Septic infants demonstrated neutropenia significantly earlier than non-septic infants but responded better to transfusion." @default.
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- W1556931679 date "1984-04-01" @default.
- W1556931679 modified "2023-09-26" @default.
- W1556931679 title "NEUTROPHIL TRANSFUSION IN THE NEWBORN: RESPONSE OF SERUM NEUTROPHIL (SN) CONCENTRATION" @default.
- W1556931679 doi "https://doi.org/10.1203/00006450-198404001-01404" @default.
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