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- W155693477 abstract "Given the fact that the vagina, the bladder trigone, and the urethrae have the highest concentration of estrogen receptors in the body, significant atrophy of these tissues should be expected with the climacteric. Vaginal atrophy is an early consequence of postmenopausal hypoestrogenemia and is an approved indication for estrogen replacement therapy. Vaginal preparations of estrogenic compounds have long been utilized for the treatment and prevention of postmenopausal symptomatology, especially those engendered by urogenital atrophy. These vaginal estrogen preparations are used by 16% of women receiving postmenopausal estrogen replacement and over two million prescriptions for such products are filled each year in the United States. Vaginal estrogens were originally believed to exert only local effects; however, data show that steroid hormones administered in this manner are quickly absorbed into the general circulation and exert significant systemic effects." @default.
- W155693477 created "2016-06-24" @default.
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- W155693477 date "2004-01-01" @default.
- W155693477 modified "2023-09-26" @default.
- W155693477 title "Estrogen Replacement, Vaginal" @default.
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- W155693477 doi "https://doi.org/10.1016/b0-12-475570-4/00457-1" @default.
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