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- W155695330 abstract "Abstract Many human globin-chain mutants contain amino acid replacements that result from single base changes in the corresponding globin gene. Using recombinants, the coding sequences of each of the alpha-, beta-, Ggamma- , and Agamma-globin genes have now been determined. Those sequences of DNA that are cleaved by a number of specific restriction endonucleases have been identified and accurately positioned. Mutations at these sequences abolish the restriction site, and therefore, the pattern of DNA fragments containing hybridizing globin-gene sequences is altered compared to DNA from normal persons. This allows the identification of one of a pair of cross-hybridizing human globin-gene sequences, as is shown here for the two alpha-globin, the two gamma-globin, and the delta- and beta-globin genes." @default.
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- W155695330 date "1980-06-01" @default.
- W155695330 modified "2023-09-28" @default.
- W155695330 title "The detection and use of hemoglobin mutants in the direct analysis of human globin genes" @default.
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- W155695330 doi "https://doi.org/10.1182/blood.v55.6.1060.1060" @default.
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