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- W1556974094 abstract "This chapter discusses a novel antipsychotic with unique D2/5-HT1A affinity and minimal extrapyramidal side effect liability. The term “neuroleptic” has been originally employed to distinguish agents for the treatment of schizophrenia from classical antidepressants or sedatives. Neuroleptic has come to signify the undesired neurological component of drug treatment and has been superseded by the use of the term antipsychotic. All marketed antipsychotics act by the antagonism of dopamine receptors in the brain, particularly those of the D2 subtype. Treatment with antipsychotics is often accompanied by untoward muscular effects, such as acute extrapyramidal symptoms (EPS) involving Parkinsonism, akathisia, and dystonia. There is an approximately 30% incidence of tardive dyskinesia involving abnormal movements, particularly of the face and tongue. Oxotremorine is a potent muscarinic agent in animals that exhibits peripheral effects, including diarrhea, salivation, lacrimation, and bradycardia and a bizarre set of central nervous system (CNS) effects featuring tremors, ataxia, and spasticity." @default.
- W1556974094 created "2016-06-24" @default.
- W1556974094 creator A5073581854 @default.
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- W1556974094 date "1995-01-01" @default.
- W1556974094 modified "2023-09-23" @default.
- W1556974094 title "Novel antipsychotics with unique D2/5-HT1A affinity and minimal extrapyramidal side effect liability" @default.
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- W1556974094 doi "https://doi.org/10.1016/s1067-5698(06)80003-9" @default.
- W1556974094 hasPublicationYear "1995" @default.
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