FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1556985106> ?p ?o ?g. }

• W1556985106 endingPage "3305" @default.
• W1556985106 startingPage "3298" @default.
• W1556985106 abstract "A molecular clone of wild mouse ecotropic retrovirus CasBrE (clone 15-1) causes a spongiform neurodegenerative disease with a long incubation period, greater than or equal to 6 months. This virus infects the central nervous system (CNS) at low levels. In contrast, a chimeric virus, FrCasE, containing env and 3' pol sequences of 15-1 in a Friend murine leukemia virus background, infects the CNS at high levels and causes a rapid neurodegenerative disease with an incubation period of only 16 days. With both viruses, the induction of neurologic disease is dependent on inoculation during the perinatal period. Since the length of the incubation period of this disease appears to be a function of the relative level of CNS infection, we have attempted to identify the viral and host factors which determine the relative level of virus infection of the CNS. It was previously shown that the CNS is susceptible to infection only during the perinatal period (M. Czub, S. Czub, F. J. McAtee, and J. L. Portis, J. Virol. 65:2539-2544, 1991). Here we have found that the susceptibility of the CNS wanes progressively or gradually as a function of the age of the host, this age-dependent resistance being complete by 12 to 14 days of age. Utilizing a group of chimeric viruses, we found that the relative level of CNS infection achieved after inoculation of mice at 1 day of age was a function of the kinetics of virus replication and spread in peripheral organs. Viruses which reached peak viremia titers early (5 to 7 days of age) infected the CNS at high levels, and viruses which reached peak titers later infected the CNS at lower levels. Among the group of viruses examined in the current study, the kinetics of peripheral virus replication and spread appeared to be influenced primarily by sequences within the R-U5-5' leader region of the viral genome. These results suggested that the relative level of CNS infection was determined very early in life and appeared to be a function of a dynamic balance between the kinetics of virus replication in the periphery and a progressively developing restriction of virus replication in the CNS." @default.
• W1556985106 created "2016-06-24" @default.
• W1556985106 creator A5038794770 @default.
• W1556985106 creator A5039111629 @default.
• W1556985106 creator A5076502313 @default.
• W1556985106 date "1992-06-01" @default.
• W1556985106 modified "2023-09-27" @default.
• W1556985106 title "Murine retrovirus-induced spongiform encephalomyelopathy: host and viral factors which determine the length of the incubation period" @default.
• W1556985106 cites W1505368702 @default.
• W1556985106 cites W1605241955 @default.
• W1556985106 cites W1656709766 @default.
• W1556985106 cites W1810181491 @default.
• W1556985106 cites W1826846253 @default.
• W1556985106 cites W1841852565 @default.
• W1556985106 cites W1904928278 @default.
• W1556985106 cites W1921452345 @default.
• W1556985106 cites W1930136272 @default.
• W1556985106 cites W1967856579 @default.
• W1556985106 cites W1969394927 @default.
• W1556985106 cites W1969930181 @default.
• W1556985106 cites W1973673458 @default.
• W1556985106 cites W1998899482 @default.
• W1556985106 cites W2001691654 @default.
• W1556985106 cites W2001936129 @default.
• W1556985106 cites W2039772552 @default.
• W1556985106 cites W2057295102 @default.
• W1556985106 cites W2061942270 @default.
• W1556985106 cites W2065707473 @default.
• W1556985106 cites W2095989475 @default.
• W1556985106 cites W2118082182 @default.
• W1556985106 cites W2146583417 @default.
• W1556985106 cites W2148059702 @default.
• W1556985106 cites W2177640702 @default.
• W1556985106 cites W2186945981 @default.
• W1556985106 cites W2273042024 @default.
• W1556985106 cites W2409714052 @default.
• W1556985106 cites W2413451022 @default.
• W1556985106 cites W567015 @default.
• W1556985106 doi "https://doi.org/10.1128/jvi.66.6.3298-3305.1992" @default.
• W1556985106 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/241107" @default.
• W1556985106 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1316449" @default.
• W1556985106 hasPublicationYear "1992" @default.
• W1556985106 type Work @default.
• W1556985106 sameAs 1556985106 @default.
• W1556985106 citedByCount "44" @default.
• W1556985106 countsByYear W15569851062013 @default.
• W1556985106 countsByYear W15569851062016 @default.
• W1556985106 countsByYear W15569851062017 @default.
• W1556985106 crossrefType "journal-article" @default.
• W1556985106 hasAuthorship W1556985106A5038794770 @default.
• W1556985106 hasAuthorship W1556985106A5039111629 @default.
• W1556985106 hasAuthorship W1556985106A5076502313 @default.
• W1556985106 hasBestOaLocation W15569851061 @default.
• W1556985106 hasConcept C104317684 @default.
• W1556985106 hasConcept C140704245 @default.
• W1556985106 hasConcept C143701427 @default.
• W1556985106 hasConcept C148632171 @default.
• W1556985106 hasConcept C159047783 @default.
• W1556985106 hasConcept C203014093 @default.
• W1556985106 hasConcept C2522874641 @default.
• W1556985106 hasConcept C25642318 @default.
• W1556985106 hasConcept C2776185481 @default.
• W1556985106 hasConcept C2778431562 @default.
• W1556985106 hasConcept C2780727368 @default.
• W1556985106 hasConcept C32611913 @default.
• W1556985106 hasConcept C54355233 @default.
• W1556985106 hasConcept C55493867 @default.
• W1556985106 hasConcept C81089528 @default.
• W1556985106 hasConcept C86803240 @default.
• W1556985106 hasConceptScore W1556985106C104317684 @default.
• W1556985106 hasConceptScore W1556985106C140704245 @default.
• W1556985106 hasConceptScore W1556985106C143701427 @default.
• W1556985106 hasConceptScore W1556985106C148632171 @default.
• W1556985106 hasConceptScore W1556985106C159047783 @default.
• W1556985106 hasConceptScore W1556985106C203014093 @default.
• W1556985106 hasConceptScore W1556985106C2522874641 @default.
• W1556985106 hasConceptScore W1556985106C25642318 @default.
• W1556985106 hasConceptScore W1556985106C2776185481 @default.
• W1556985106 hasConceptScore W1556985106C2778431562 @default.
• W1556985106 hasConceptScore W1556985106C2780727368 @default.
• W1556985106 hasConceptScore W1556985106C32611913 @default.
• W1556985106 hasConceptScore W1556985106C54355233 @default.
• W1556985106 hasConceptScore W1556985106C55493867 @default.
• W1556985106 hasConceptScore W1556985106C81089528 @default.
• W1556985106 hasConceptScore W1556985106C86803240 @default.
• W1556985106 hasIssue "6" @default.
• W1556985106 hasLocation W15569851061 @default.
• W1556985106 hasLocation W15569851062 @default.
• W1556985106 hasLocation W15569851063 @default.
• W1556985106 hasLocation W15569851064 @default.
• W1556985106 hasOpenAccess W1556985106 @default.
• W1556985106 hasPrimaryLocation W15569851061 @default.
• W1556985106 hasRelatedWork W1487857142 @default.
• W1556985106 hasRelatedWork W1511818607 @default.
• W1556985106 hasRelatedWork W1573961143 @default.
• W1556985106 hasRelatedWork W1921452345 @default.
• W1556985106 hasRelatedWork W1971057287 @default.
• W1556985106 hasRelatedWork W2029861232 @default.

• next