Matches in SemOpenAlex for { <https://semopenalex.org/work/W1557007539> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W1557007539 endingPage "165" @default.
- W1557007539 startingPage "145" @default.
- W1557007539 abstract "Rabbit hemorrhagic disease virus (RHDV) causes great losses and is life threatening to both wild and domestic rabbits. This work represents the first step toward production of transgenic rabbits resistant to RHDV by RNAi through the inhibition of expression of a part of the RHDV genome and the consequent inhibition of its multiplication. This part of RHDV genome is available under the accession EU003582.1 in NCBI from the nucleotide 372 to 392 (McIntosh et al., 2007). Chinese Hamster Ovary (CHO) cell line was transfected with a plasmid harboring the RHDV target in the DNA segment coding for luciferase (fusion protein) and co-transfected with another plasmid harboring a DNA sequence designed to code for a homologous double stranded RNA sequence of 21 pb. This sequence acts as siRNA to inhibit the expression of the viral genomic part through RNAi. The series of co-transfection resulted in an inhibition level ranging from 82 to 87% of expression of the fusion protein and consequently of the RHDV target. These results are encouraging. However, further investigations are necessary to obtain more inhibition ex-vivo with validation in vivo using transgenic rabbits." @default.
- W1557007539 created "2016-06-24" @default.
- W1557007539 creator A5062792749 @default.
- W1557007539 date "2008-04-01" @default.
- W1557007539 modified "2023-10-12" @default.
- W1557007539 title "RNAi Inhibition of Rabbit Hemorrhagic Disease Virus (RHDV) Gene Expression in CHO Cell Line" @default.
- W1557007539 cites W144209598 @default.
- W1557007539 cites W1491459594 @default.
- W1557007539 cites W1558571012 @default.
- W1557007539 cites W1611419331 @default.
- W1557007539 cites W1980865681 @default.
- W1557007539 cites W1982986505 @default.
- W1557007539 cites W1994207095 @default.
- W1557007539 cites W2003007930 @default.
- W1557007539 cites W2005646919 @default.
- W1557007539 cites W2017733353 @default.
- W1557007539 cites W2018403717 @default.
- W1557007539 cites W2034206562 @default.
- W1557007539 cites W2051144618 @default.
- W1557007539 cites W2073131173 @default.
- W1557007539 cites W2075814758 @default.
- W1557007539 cites W2076061954 @default.
- W1557007539 cites W2099956255 @default.
- W1557007539 cites W2113768610 @default.
- W1557007539 cites W2124086379 @default.
- W1557007539 cites W2138664009 @default.
- W1557007539 cites W2144634347 @default.
- W1557007539 cites W2175926451 @default.
- W1557007539 cites W2283259862 @default.
- W1557007539 cites W2468658448 @default.
- W1557007539 cites W73476825 @default.
- W1557007539 doi "https://doi.org/10.35552/anujr.a.22.1.535" @default.
- W1557007539 hasPublicationYear "2008" @default.
- W1557007539 type Work @default.
- W1557007539 sameAs 1557007539 @default.
- W1557007539 citedByCount "1" @default.
- W1557007539 countsByYear W15570075392015 @default.
- W1557007539 crossrefType "journal-article" @default.
- W1557007539 hasAuthorship W1557007539A5062792749 @default.
- W1557007539 hasBestOaLocation W15570075391 @default.
- W1557007539 hasConcept C102230213 @default.
- W1557007539 hasConcept C104317684 @default.
- W1557007539 hasConcept C153911025 @default.
- W1557007539 hasConcept C159047783 @default.
- W1557007539 hasConcept C166703698 @default.
- W1557007539 hasConcept C175656101 @default.
- W1557007539 hasConcept C22744801 @default.
- W1557007539 hasConcept C2522874641 @default.
- W1557007539 hasConcept C54009773 @default.
- W1557007539 hasConcept C54355233 @default.
- W1557007539 hasConcept C67705224 @default.
- W1557007539 hasConcept C81885089 @default.
- W1557007539 hasConcept C86803240 @default.
- W1557007539 hasConceptScore W1557007539C102230213 @default.
- W1557007539 hasConceptScore W1557007539C104317684 @default.
- W1557007539 hasConceptScore W1557007539C153911025 @default.
- W1557007539 hasConceptScore W1557007539C159047783 @default.
- W1557007539 hasConceptScore W1557007539C166703698 @default.
- W1557007539 hasConceptScore W1557007539C175656101 @default.
- W1557007539 hasConceptScore W1557007539C22744801 @default.
- W1557007539 hasConceptScore W1557007539C2522874641 @default.
- W1557007539 hasConceptScore W1557007539C54009773 @default.
- W1557007539 hasConceptScore W1557007539C54355233 @default.
- W1557007539 hasConceptScore W1557007539C67705224 @default.
- W1557007539 hasConceptScore W1557007539C81885089 @default.
- W1557007539 hasConceptScore W1557007539C86803240 @default.
- W1557007539 hasLocation W15570075391 @default.
- W1557007539 hasOpenAccess W1557007539 @default.
- W1557007539 hasPrimaryLocation W15570075391 @default.
- W1557007539 hasRelatedWork W1530386916 @default.
- W1557007539 hasRelatedWork W1982207984 @default.
- W1557007539 hasRelatedWork W1992995998 @default.
- W1557007539 hasRelatedWork W2044686496 @default.
- W1557007539 hasRelatedWork W2359175313 @default.
- W1557007539 hasRelatedWork W2389697466 @default.
- W1557007539 hasRelatedWork W2915002842 @default.
- W1557007539 hasRelatedWork W2929763278 @default.
- W1557007539 hasRelatedWork W3123814123 @default.
- W1557007539 hasRelatedWork W4281625450 @default.
- W1557007539 isParatext "false" @default.
- W1557007539 isRetracted "false" @default.
- W1557007539 magId "1557007539" @default.
- W1557007539 workType "article" @default.