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• W1557051865 endingPage "11998" @default.
• W1557051865 startingPage "11993" @default.
• W1557051865 abstract "Valyl-tRNA synthetase from mammalian cells is isolated in a high Mr complex with elongation factor 1 (EF-1). This complex, which represents all of the valyl-tRNA synthetase activity and a significant portion of the EF-1 activity in rabbit reticulocytes, contains five polypeptides identified as valyl-tRNA synthetase and the four subunits of EF-1. In this study, we have examined the potential for regulation of the complex by phosphorylation of these components. The valyl-tRNA synthetase.EF-1 complex has been purified by gel filtration and tRNA-Sepharose chromatography from 32P-labeled rabbit reticulocytes stimulated by phorbol 12-myristate 13-acetate (PMA) and compared to the complex purified from control cells. One- and two-dimensional polyacrylamide gel electrophoresis and autoradiography show that valyl-tRNA synthetase and the alpha, beta and delta subunits of EF-1 are phosphorylated in vivo. Phosphorylation of each of the four proteins is increased 2-4-fold in response to PMA. Phosphorylation of valyl-tRNA synthetase in response to PMA is reproducibly accompanied by a 1.7-fold increase in aminoacylation activity, whereas phosphorylation of EF-1 is associated with a 2.0-2.2-fold stimulation of activity, as measured by poly(U)-directed polyphenylalanine synthesis. These data suggest that stimulation of translational rates in response to PMA is mediated, at least in part, by phosphorylation of valyl-tRNA synthetase and EF-1." @default.
• W1557051865 created "2016-06-24" @default.
• W1557051865 creator A5006211588 @default.
• W1557051865 creator A5033948222 @default.
• W1557051865 creator A5068814744 @default.
• W1557051865 date "1991-06-01" @default.
• W1557051865 modified "2023-10-18" @default.
• W1557051865 title "Phosphorylation of valyl-tRNA synthetase and elongation factor 1 in response to phorbol esters is associated with stimulation of both activities" @default.
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• W1557051865 doi "https://doi.org/10.1016/s0021-9258(18)99055-1" @default.
• W1557051865 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2050694" @default.
• W1557051865 hasPublicationYear "1991" @default.
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