FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1557147130> ?p ?o ?g. }

• W1557147130 endingPage "3886" @default.
• W1557147130 startingPage "3881" @default.
• W1557147130 abstract "Capitalizing on the significant sequence homology comprising the transmembrane motif regions of known prostanoid receptor family, we targeted the cloning of a cDNA clone for prostaglandin (PG) F2 alpha receptor from a bovine corpus luteum cDNA library. By using several pairs of degenerated primers created from a common motif of transmembrane domains, polymerase chain reaction gave a clone SN463 carrying the homologous sequence, which covered transmembrane motif IV-VI of the thromboxane (TX) A2 receptor. This polymerase chain reaction product was used as a DNA probe for the following cross-hybridization, and a clone BC2211 carrying a 2.2-kilobase pair DNA insert was isolated. This clone encodes a protein of 362 amino acid residues (M(r) = 40,983) with seven potential transmembrane domains and represented significant overall sequence homology to human TXA2 receptor protein (34% in amino acid). Injection of the mRNA synthesized in vitro from the cloned cDNA into a Xenopus oocyte elicited electrophysiological response to PGF2 alpha. Ligand binding displacement in membranes of mammalian COS-7 cells transfected with the cDNA indicated the rank order of affinity of the receptor to PGs: PGF2 alpha > PGD2 > PGE2 > STA2, a TXA2 agonist. PGF2 alpha activated inositol phosphate formation in COS-7 cells transfected with receptor cDNA. Northern blot analysis and in situ hybridization indicated that the PGF2 alpha receptor mRNA is highly expressed and accumulated in corpus luteum. This is the first report on a successful cloning of functional receptor cDNA for PGF2 alpha." @default.
• W1557147130 created "2016-06-24" @default.
• W1557147130 creator A5010490492 @default.
• W1557147130 creator A5018171493 @default.
• W1557147130 creator A5023834571 @default.
• W1557147130 creator A5025054004 @default.
• W1557147130 creator A5034802768 @default.
• W1557147130 creator A5057261704 @default.
• W1557147130 creator A5062565824 @default.
• W1557147130 creator A5064701201 @default.
• W1557147130 date "1994-02-01" @default.
• W1557147130 modified "2023-10-17" @default.
• W1557147130 title "Molecular cloning and expression of a cDNA of the bovine prostaglandin F2 alpha receptor." @default.
• W1557147130 cites W1523969239 @default.
• W1557147130 cites W1527412488 @default.
• W1557147130 cites W1531815379 @default.
• W1557147130 cites W1546944401 @default.
• W1557147130 cites W1577723117 @default.
• W1557147130 cites W1673414420 @default.
• W1557147130 cites W1964377967 @default.
• W1557147130 cites W1964838850 @default.
• W1557147130 cites W1971260745 @default.
• W1557147130 cites W1972995848 @default.
• W1557147130 cites W1975304761 @default.
• W1557147130 cites W1977377809 @default.
• W1557147130 cites W1984590208 @default.
• W1557147130 cites W1988298211 @default.
• W1557147130 cites W2013430170 @default.
• W1557147130 cites W2018218145 @default.
• W1557147130 cites W2021018995 @default.
• W1557147130 cites W2039202862 @default.
• W1557147130 cites W2039386604 @default.
• W1557147130 cites W2048009051 @default.
• W1557147130 cites W2065137188 @default.
• W1557147130 cites W2071596004 @default.
• W1557147130 cites W2074883524 @default.
• W1557147130 cites W2078547715 @default.
• W1557147130 cites W2081688069 @default.
• W1557147130 cites W2084914309 @default.
• W1557147130 cites W2094944495 @default.
• W1557147130 cites W2129510413 @default.
• W1557147130 cites W2149736282 @default.
• W1557147130 cites W2304638861 @default.
• W1557147130 cites W4248634331 @default.
• W1557147130 cites W4294216491 @default.
• W1557147130 doi "https://doi.org/10.1016/s0021-9258(17)41942-9" @default.
• W1557147130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7508922" @default.
• W1557147130 hasPublicationYear "1994" @default.
• W1557147130 type Work @default.
• W1557147130 sameAs 1557147130 @default.
• W1557147130 citedByCount "117" @default.
• W1557147130 countsByYear W15571471302013 @default.
• W1557147130 countsByYear W15571471302014 @default.
• W1557147130 countsByYear W15571471302015 @default.
• W1557147130 countsByYear W15571471302016 @default.
• W1557147130 countsByYear W15571471302017 @default.
• W1557147130 countsByYear W15571471302018 @default.
• W1557147130 countsByYear W15571471302019 @default.
• W1557147130 countsByYear W15571471302022 @default.
• W1557147130 crossrefType "journal-article" @default.
• W1557147130 hasAuthorship W1557147130A5010490492 @default.
• W1557147130 hasAuthorship W1557147130A5018171493 @default.
• W1557147130 hasAuthorship W1557147130A5023834571 @default.
• W1557147130 hasAuthorship W1557147130A5025054004 @default.
• W1557147130 hasAuthorship W1557147130A5034802768 @default.
• W1557147130 hasAuthorship W1557147130A5057261704 @default.
• W1557147130 hasAuthorship W1557147130A5062565824 @default.
• W1557147130 hasAuthorship W1557147130A5064701201 @default.
• W1557147130 hasBestOaLocation W15571471301 @default.
• W1557147130 hasConcept C104292427 @default.
• W1557147130 hasConcept C104317684 @default.
• W1557147130 hasConcept C121050878 @default.
• W1557147130 hasConcept C153911025 @default.
• W1557147130 hasConcept C159110408 @default.
• W1557147130 hasConcept C164083038 @default.
• W1557147130 hasConcept C170493617 @default.
• W1557147130 hasConcept C187882448 @default.
• W1557147130 hasConcept C19924922 @default.
• W1557147130 hasConcept C199360897 @default.
• W1557147130 hasConcept C206412730 @default.
• W1557147130 hasConcept C2775944032 @default.
• W1557147130 hasConcept C2777187973 @default.
• W1557147130 hasConcept C41008148 @default.
• W1557147130 hasConcept C49453240 @default.
• W1557147130 hasConcept C54355233 @default.
• W1557147130 hasConcept C64943373 @default.
• W1557147130 hasConcept C71924100 @default.
• W1557147130 hasConcept C83730767 @default.
• W1557147130 hasConcept C86803240 @default.
• W1557147130 hasConceptScore W1557147130C104292427 @default.
• W1557147130 hasConceptScore W1557147130C104317684 @default.
• W1557147130 hasConceptScore W1557147130C121050878 @default.
• W1557147130 hasConceptScore W1557147130C153911025 @default.
• W1557147130 hasConceptScore W1557147130C159110408 @default.
• W1557147130 hasConceptScore W1557147130C164083038 @default.
• W1557147130 hasConceptScore W1557147130C170493617 @default.
• W1557147130 hasConceptScore W1557147130C187882448 @default.
• W1557147130 hasConceptScore W1557147130C19924922 @default.

• next