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• W1557213725 abstract "Background: Both elevated non-HDL cholesterol (C) and elevated blood pressure (BP) are major risk factors for the development and targets for the prevention of atherothrombotic disease. Possible interactions between these two parameters have not been studied in detail. This investigation aims at looking at values of blood serum cholesterol, blood pressure and pos- sible correlations therein in men and women, with a special focus on the impact of age. Methods: A total of 7496 outpatients with arterial hyperten- sion in Austria were recruited. Four age groups were analyzed (≤ 49 years, 50-59 years, 60-69 years and ≥ 70 years). Results: Overall, men and women had similar systolic and diastolic blood pressure (158 ± 91 vs 159 ± 19 mmHg and 91 ± 10 vs 91 ± 11 mmHg, respectively; p < 0.01) and similar non-HDL C values (165 ± 45 mg/dl; 164 ± 43 mg/dl, resp.; p < 0.001). Both, systolic (SBP) and diastolic (DBP) blood pressure correlated highly significantly with non-HDL (p < 0.001) in men (mean r = 0.15 for SBP and r = 0.18 for DBP, both p < 0.001). Women showed a weaker corre- lation with a mean r = 0.10 for SBP and r = 0.09 for DBP (both p < 0.001). With respect to the four age groups, non-HDL C was similar in men be- tween 172 ± 47 and 173 ± 44 mg/dl up to the age of 60 years and declined to 157 ± 43 mg/dl in the group above 70 years of age. In women we de- tected a rise of non-HDL C by 10 mg/dl around menopause (mean 158 ± 42 mg/dl < 50 years of age, mean 168 ± 42 mg/dl with 50-59 years, af- terwards declining to 163 ± 43 mg/dl; p < 0.01). SBP was similar in men and women over all age groups (between 157 ± 19 and 159 ± 19 mmHg), whereas DBP declined with increasing age (95 ± 10 to 88 ± 11 mmHg in men; 94 ± 11 to 88 ± 11 mmHg, resp.). Correlations between SBP, DBP and non-HDL cholesterol were greater for men. Women showed an increase around menopause. Conclusion: Our results demonstrate a correla- tion of non-HDL C and blood pressure in hyper- tensive men of all age groups. In women, meno- pause has a significant influence not only on lipid levels, but also on correlations to blood pressure." @default.
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• W1557213725 date "2012-02-07" @default.
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• W1557213725 title "Is there a Link Between Non-HDL Cholesterol and Blood Pressure? An Age and Gender Directed Analysis of 7500 Hypertensive Outpatients" @default.
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