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- W1557255780 abstract "Scopularide A is a promising potent anticancer lipopeptide isolated from a marine derived Scopulariopsis brevicaulis strain. The compound consists of a reduced carbon chain (3-hydroxy-methyldecanoyl) attached to five amino acids (glycine, l-valine, d-leucine, l-alanine, and l-phenylalanine). Using the newly sequenced S. brevicaulis genome we were able to identify the putative biosynthetic gene cluster using genetic information from the structurally related emericellamide A from Aspergillus nidulans and W493-B from Fusarium pseudograminearum. The scopularide A gene cluster includes a nonribosomal peptide synthetase (NRPS1), a polyketide synthase (PKS2), a CoA ligase, an acyltransferase, and a transcription factor. Homologous recombination was low in S. brevicaulis so the local transcription factor was integrated randomly under a constitutive promoter, which led to a three to four-fold increase in scopularide A production. This indirectly verifies the identity of the proposed biosynthetic gene cluster." @default.
- W1557255780 created "2016-06-24" @default.
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- W1557255780 date "2015-07-14" @default.
- W1557255780 modified "2023-10-14" @default.
- W1557255780 title "Identification of the Scopularide Biosynthetic Gene Cluster in Scopulariopsis brevicaulis" @default.
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- W1557255780 doi "https://doi.org/10.3390/md13074331" @default.
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